Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
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DOI：
10.1161/01.cir.101.15.1767
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发表时间：
2000-04-18
期刊：
影响因子：
37.8
通讯作者：
Hennekens, CH
中科院分区：
文献类型：
--
作者：
Ridker, PM;Rifai, N;Hennekens, CH
白细胞介素-6 （IL-6）在炎症和组织损伤中起核心作用。然而，评估IL-6在动脉粥样硬化中的作用的流行病学数据很少。方法和结果：在一项涉及14916名明显健康男性的前瞻性研究中，我们测量了202名随后发生心肌梗死（MI）的参与者和202名年龄和吸烟状况相匹配的研究参与者的基线血浆IL-6浓度，这些参与者在6年随访期间没有报告血管疾病。基线时IL-6的中位浓度在随后发生心肌梗死的男性中高于未发生心肌梗死的男性（1.81对1.46 pg/mL； P=0.002）。未来心肌梗死的风险随着基线IL-6浓度的增加而增加（趋势P < 0.001），因此进入时最高四分位数的男性的相对风险是最低四分位数的3.3倍（95% CI 1.3至4.3，P=0.005）；IL-6每增加四分位数，风险增加38% （P=0.001）。在调整其他心血管危险因素后，这种关系仍然显著，在长时间的随访中保持稳定，并存在于所有低风险亚组中，包括不吸烟者。尽管这些数据中与IL-6相关性最强的是c反应蛋白（r=0.43, P < 0.001），但在控制该因素后，IL-6与后续风险的关系仍然存在（P < 0.001）。结论：在表面健康的男性中，IL-6水平升高与未来心肌梗死的风险增加有关。因此，这些数据支持细胞因子介导的炎症在动脉粥样硬化早期阶段的作用。
Background-Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse.Methods and Results-In a prospective study involving 14 916 apparently healthy men, we measured baseline plasma concentration of IL-6 in 202 participants who subsequently developed myocardial infarction (MI) and in 202 study participants matched for age and smoking status who did not report vascular disease during a 6-year follow-up. Median concentrations of IL-6 at baseline were higher among men who subsequently had an MI than among those who did not (1.81 versus 1.46 pg/mL; P=0.002). The risk of future MI increased with increasing quartiles of baseline IL-6 concentration (P for trend < 0.001) such that men in the highest quartile at entry had a relative risk 3.3 times higher than those in the lowest quartile (95% CI 1.3 to 4.3, P=0.005); for each quartile increase in IL-6, there was a 38% increase in risk (P=0.001). This relationship remained significant after adjustment for other cardiovascular risk factors, was stable over long periods of follow-up, and was present in all low-risk subgroups, including nonsmokers. Although the strongest correlate of IL-6 in these data was C-reactive protein (r=0.43, P < 0.001), the relationship of IL-6 with subsequent risk remained after control for this factor (P < 0.001).Conclusions-In apparently healthy men, elevated levels of IL-6 are associated with increased risk of future MI. These data thus support a role for cytokine-mediated inflammation in the early stages of atherogenesis.