Mild Aminoacylation of Indoles and Pyrroles through a Three-Component Reaction with Ynol Ethers and Sulfonyl Azides
Mild Aminoacylation of Indoles and Pyrroles through a Three-Component Reaction with Ynol Ethers and Sulfonyl Azides
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DOI：
10.1021/ja5058967
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发表时间：
2014-07-23
影响因子：
15
通讯作者：
Davies, Huw M. L.
中科院分区：
文献类型：
--
作者：
Alford, Joshua S.;Davies, Huw M. L.
研究了吲哚和吡咯的氨酰化反应。该转化涉及吲哚或吡咯、炔醇醚和磺酰叠氮之间的多组分一锅级联反应，通过N-磺酰三唑中间体区域选择性地产生四种不同的键。氧代色胺和氧代吡咯乙胺在温和的反应条件下以中等至高产率产生。
An effective method for aminoacylation of indoles and pyrroles has been achieved. The transformation involves a multicomponent one-pot cascade reaction between indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediates. The oxo-tryptamines and oxo-pyrroloethanamines are generated in moderate to high yields under mild reaction conditions.