Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea
Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea
复制标题
DOI：
10.1016/j.sleep.2011.07.015
复制
发表时间：
2012-01-01
期刊：
影响因子：
4.8
通讯作者：
Ip, Mary S. M.
中科院分区：
文献类型：
--
作者：
Lam, Jamie C. M.;Tan, Kathryn C. B.;Ip, Mary S. M.
背景资料：已知糖尿病患者血清中晚期糖基化终产物（AGEs）水平升高，这也与胰岛素抵抗相关。本研究旨在探讨血清AGEs和胰岛素敏感性之间的关系，在非糖尿病受试者阻塞性睡眠呼吸暂停（OSA）。他们在实验室进行了整夜的多导睡眠图检查。空腹取血测定血清AGE和血糖水平。结果：共分析了105例受试者，平均年龄43.5（标准差[SD] 9.2）岁，平均体重指数27.1（SD 4.0）kg/m2，平均呼吸暂停低通气指数（AHI）17（四分位数间距5-46）。OSA患者（AHI ≥ 5）血清AGE水平显著高于非OSA患者（AHI
Background: Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. This study aimed to investigate the relationship between serum AGEs and insulin sensitivity in non-diabetic subjects with obstructive sleep apnoea (OSA).Methods: Adult males with no known comorbidities were recruited from the sleep clinic of a university teaching hospital. They underwent overnight in-laboratory polysomnography. Fasting blood was taken to measure serum AGE and plasma glucose levels. Insulin sensitivity was estimated using the short insulin tolerance test.Results: In total, 105 subjects with a mean age of 43.5 (standard deviation [SD] 9.2) years, mean body mass index of 27.1 (SD 4.0) kg/m(2), and median apnoea-hypopnoea index (AHI) of 17 (interquartile range 5-46) were analysed. Serum AGE levels were significantly higher in subjects with OSA (AHI >= 5), compared with those without OSA (AHI