SEXUAL-BEHAVIOR - ITS GENETIC-CONTROL DURING DEVELOPMENT AND ADULTHOOD IN DROSOPHILA-MELANOGASTER
SEXUAL-BEHAVIOR - ITS GENETIC-CONTROL DURING DEVELOPMENT AND ADULTHOOD IN DROSOPHILA-MELANOGASTER
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DOI：
10.1073/pnas.84.22.8026
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发表时间：
1987-11-01
影响因子：
11.1
通讯作者：
BAKER, BS
中科院分区：
文献类型：
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作者：
BELOTE, JM;BAKER, BS
果蝇的求偶行为是一种与生俱来的行为模式。一只苍蝇是否会表现出雄性求偶行为是由一组调控基因的作用决定的，这些基因控制着体细胞性分化的各个方面。这些调控基因之一的野生型功能，Transformer-2（tra-2），是女性性分化所必需的;在缺乏tra-2+功能的情况下，XX个体分化为男性。一个温度敏感的tra-2等位基因已被用来调查，通过温度变化，何时以及如何在发展过程中指定的男性求偶行为。在成虫中去除tra-2 ts功能（通过将tra-2 ts突变果蝇转移到限制性温度）可以导致果蝇出现雄性求偶行为，否则这些行为不会显示。这些实验表明，控制性分化的调节层次在成人中枢神经系统中起作用。更重要的是，这些结果表明，成人中枢神经系统具有一定的功能可塑性方面的先天行为模式的男性求偶，并保持在一个特定的状态的分化，在成人的基因表达的主动控制。
Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.