Castration reverses immunosenescence in aged mice
Castration reverses immunosenescence in aged mice
复制标题
去势逆转老年小鼠的免疫衰老
DOI：
10.1038/aps.2011.110
复制
发表时间：
2011-08
影响因子：
8.2
通讯作者：
Wei, Wei
中科院分区：
文献类型：
--
作者：
Yan, Shang-xue;Wei, Wei
The increasing aged population poses new challenges to healthcare systems. The elderly frequently suffers from severe infections and end-stage organ disease, which are associated with an age-dependent decline in immune reactivity [1, 2]. Immunosenescence, defined as the changes in the immune system associated with age, is gathering interest in the scientific and healthcare communities alike.Immunosenescence is generally related with weaker immune responses, which produce a progressive deterioration in the ability to respond to new stimulants. One might expect the elderly to be less reactive against transplanted organs than younger patients, thus to show better transplant outcomes. It is reasonable to assume that older individuals would be more easily rendered tolerant of transplanted organs [3]. Paradoxically, experimental studies and clinical data of organ transplantation have shown that the graft is more rapidly rejected in the elderly than in the younger. Thus, the age-related muting of the immune responses does not improve tolerance induction and reduce rejection after cell or organ transplantation. The effects of aging on acute and chronic allograft rejection have been extensively studied [4]. Many researches showed that the effects of immunose-
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影响因子：
15.3
作者：
Haynes, L;Eaton, SM;Burns, EM;Randall, TD;Swain, SL
通讯作者：
Swain, SL
影响因子：
158.5
作者：
Markert, ML;Boeck, A;Mahaffey, SM
通讯作者：
Mahaffey, SM
可能影响免疫衰老的因素：评估。
影响因子：
7.9
作者：
Ongradi, Joseph;Kovesdi, Valeria
通讯作者：
Kovesdi, Valeria
DOI：
10.1177/107327480000700603
发表时间：
2000-11
期刊：
Cancer control : journal of the Moffitt Cancer Center
影响因子：
--
作者：
E. Burns;E. Leventhal
通讯作者：
E. Burns;E. Leventhal
影响因子：
17.1
作者：
Zhao G;Moore DJ;Kim JI;Lee KM;O'Connor MR;Duff PE;Yang M;Lei J;Markmann JF;Deng S
通讯作者：
Deng S