Peripheral Vascular Responses of Men and Women to LBNP
Peripheral Vascular Responses of Men and Women to LBNP
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DOI：
10.3357/asem.3174.2012
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发表时间：
2012-02-01
影响因子：
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通讯作者：
Blaber, Andrew P.
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文献类型：
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作者：
Hachiya, Tesshin;Hashimoto, Isamu;Blaber, Andrew P.
HACHIYA T，HASHIMOTO I，SAITO M，BLABER AP.男性和女性对LBNP的外周血管反应。Aviat Space Environ Med 2012;83：118- 24.背景：本研究检验了女性在分级下体负压（LBNP）期间小腿血管收缩反应较小的假设。方法：采用近红外光谱法（NIRS）测定小牛血液中的深氧合血红蛋白（Hb），观察其血流变化。11名男性和9名女性志愿者接受了高达60 mm的分级LBNP图。心血管反应通过以下方法测量：前臂和小腿浅部和深部的NIRS用于氧合和脱氧Hb;汞应变计体积描记法用于小腿血液池;心电图用于心率;光电体积描记法用于血压、心输出量和总外周阻力。结果如下：女性的心输出量较低，总外周阻力较高;然而，男性和女性的心输出量降低和总外周阻力增加与LBNP相似。在整个LBNP期间，前臂氧合血红蛋白从基线开始下降，男性和女性之间无差异。女性受试者与男性受试者相比，LBNP的血液汇集增加率更高。在LBNP过程中，男性的选择性深小腿氧合Hb降低幅度大于女性。此外，当用回归分析检查氧合HI反应作为小牛血液汇集的函数时，男性的斜率（-0.62 +/- 0.05）大于女性（-0.33 +/- 0.04）。结论：在男性受试者中，在给定的血液汇集和每个负压下，氧合血红蛋白的斜率更大，这使我们得出结论，在分级LBNP期间，男性的小腿血管收缩反应更大。
HACHIYA T, HASHIMOTO I, SAITO M, BLABER AP. Peripheral vascular responses of men and women to LBNP. Aviat Space Environ Med 2012;83:118-24.Background: This study examined the hypothesis that women exhibit smaller vasoconstrictor responses in the calf during graded lower body negative pressure (LBNP). Methods: Selective deep oxygenated hemoglobin (Hb) assessed by near-infrared spectroscopy (NIRS) was used to examine blood flow changes in the calf. Eleven men and nine women volunteers underwent graded LBNP up to 60 mm Fig. Cardiovascular responses were measured by: NIRS on the forearm and superficial and deep calf for oxygenated and deoxygenated Hb; mercury strain gauge plethysmography for calf blood pooling; electrocardiogram for heart rate; and, photoplethysmography for blood pressure, cardiac output, and total peripheral resistance. Results: Cardiac output was lower and total peripheral resistance higher in women; however, both men and women had similar decreases in cardiac output and increases in total peripheral resistance with LBNP. Forearm oxygenated Hb decreased from baseline throughout LBNP, and no difference was found between men and women. Female subjects had greater rates of increased blood pooling with LBNP than their male counterparts. Men had greater selective deep calf oxygenated Hb reductions compared to women during LBNP. Moreover, when the oxygenated HI) response as a function of calf blood pooling was examined with regression analyses, men had greater slopes (-0.62 +/- 0.05) than women (-0.33 +/- 0.04). Conclusion: The greater slopes in oxygenated Hb at given blood pooling and at each negative pressure in male subjects led us to conclude that men had greater vasoconstrictor responses in the calf during graded LBNP.