DIETARY RESTRICTION BENEFITS LEARNING AND MOTOR-PERFORMANCE OF AGED MICE
DIETARY RESTRICTION BENEFITS LEARNING AND MOTOR-PERFORMANCE OF AGED MICE
复制标题
DOI：
10.1093/geronj/42.1.78
复制
发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
WALFORD, RL
中科院分区：
文献类型：
--
作者：
INGRAM, DK;WEINDRUCH, R;WALFORD, RL
雌性C3 B10 RF 1小鼠维持在对照（约95千卡/周）或限制（. apprx. 55千卡/周）的饮食，在11至15或31至35月龄（中年与老年）的行为电池中进行测试。在运动协调（旋转棒）和学习（复杂迷宫）测试中，在对照组中观察到的与运动相关的下降被限制方案所阻止。此外，饮食限制增加了两个年龄段小鼠在跑轮笼中的运动活动，但不影响在新竞技场中的探索活动。
Female C3B10RF1 mice maintained on either a control (.apprx. 95 kcal/week) or restricted (.apprx. 55 kcal/week) diet since weaning were tested in a behavioral battery at 11 to 15 or 31 to 35 months of age (middle-aged vs. aged). Age-related declines observed among control groups in tests of motor coordination (rotorod) and learning (complex maze) were prevented by the restriction regime. In addition, diet restriction increased locomotor activity in a runwheel cage among mice of both ages but did not affect exploratory activity in a novel arena.