Determination of tetrabromobisphenol-A/S and their main derivatives in water samples by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry
Determination of tetrabromobisphenol-A/S and their main derivatives in water samples by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry
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高效液相色谱-电感耦合等离子体串联质谱法测定水样中四溴双酚-A/S及其主要衍生物
DOI：
10.1016/j.chroma.2017.03.040
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发表时间：
2017-05-12
影响因子：
4.1
通讯作者：
Jiang, Guibin
中科院分区：
文献类型：
--
作者：
Liu, Lihong;Liu, Aifeng;Jiang, Guibin
四溴双酚-A(TBBPA)及其替代物四溴双酚-S(TBBPS)及其衍生物作为目前应用最广泛的溴化阻燃剂，因其对人体健康的危害而受到广泛关注，因此迫切需要对其进行灵敏的检测。建立了一种高效液相色谱-电感耦合等离子体质谱(ICPMS/MS)联用技术测定水样中的2，3-二溴丙基醚(TBBPA-BDBPE)、2，3-二溴丙基醚(TBBPA-BDBPE)及其衍生物。优化后，用电感耦合等离子体质谱(ICMS)同时灵敏地测定了溴(m/z=79)。方法的仪器检出限分别为0.12、0.14、0.19、0.14、0.12、0.17、0.13 mg L-1，接近或明显优于文献报道的方法。日内分析的峰面积和保留时间的相对标准偏差(RSD，n=5)分别小于2.2%和0.2%，重复性好，精密度高。方法用于水样中对苯二酚/S及其衍生物的分析，回收率为67.7%~4.13%。(C)2017爱思唯尔B.V.保留所有权利。
As the most widely used brominated flame retardants (BFRs), Tetrabromobisphenol-A (TBBPA) as well as its alternative Tetrabromobisphenol-S (TBBPS) and their derivatives have raised wide concerns due to their adverse effects on human health and hence the sensitive detection of those BFRs was urgently needed. Herein, a novel analytical method based on high-performance liquid chromatography (HPLC) coupled with inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) has been developed for the determination of TBBPA/S and their derivatives, including TBBPA-bis(2-hydroxyethyl ether) (TBBPA-BHEE), TBBPA-bis(allylether) (TBBPA-BAE), TBBPA-bis(glycidyl ether) (TBBPA-BGE), TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) and TBBPS-bis(2,3-dibromopropyl ether) (TBBPS-BDBPE) in water samples. After optimization, the TBBPA/S and their derivatives, especially the TBBPA-BAE and TBBPA-BDBPE were simultaneously and sensitively quantified by determination of bromine (m/z= 79) by using the ICP-MS. The instrument limits of detection (LODs) for the TBBPA, TBBPA-BHEE, TBBPA-BGE, TBBPA-BAE, TBBPA-BDBPE, TBBPS and TBBPS-BDBPE were determined to be 0.12, 0.14, 0.19, 0.14, 0.12, 0.17 and 0.13 mu g L-1, respectively, which was close to or much better than the reported methods. The relative standard deviations (RSDs, n = 5) of peak area and retention time were better than 2.2% and 0.2% for intra-day analysis, indicating good repeatability and high precision. The proposed method had been successfully applied for the analysis of TBBPA/S and their derivatives in water samples with satisfactory recoveries (67.7%4 13%). (C) 2017 Elsevier B.V. All rights reserved.