Principles of human and mouse nephron development.
Principles of human and mouse nephron development.
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人类和小鼠肾单位发育的原理。
DOI：
10.1038/s41581-022-00598-5
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Lindström,NilsOlof
中科院分区：
文献类型：
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作者：
Schnell,Jack;Achieng,MaryAnne;Lindström,NilsOlof
小鼠和人类肾脏发育的潜在机制是一个深入研究的领域。对肾脏器官发生的深入了解有可能指导我们理解先天性异常的起源，并使遗传诊断工具的组装成为可能。一些研究已经描绘了信号节点，调节肾单位祖细胞和前体细胞的位置身份和细胞命运，而跨物种的比较显着提高了我们的理解保守和不同的功能，哺乳动物肾脏器官发生。随着近端-远端轴的建立，对复杂细胞运动的更深入了解挑战了我们对肾单位模式的理解，并为人类肾脏疾病可能出现的复杂发育背景提供了重要线索。对体内肾脏发育的研究还通过提供信号传导事件、细胞运动和图案化机制的详细蓝图，促进了在体外重演肾脏类器官中的肾发生的努力，这些信号传导事件、细胞运动和图案化机制是形成正确图案化的肾单位和负责维持人类健康的生理功能装置成熟所需的。
The mechanisms underlying kidney development in mice and humans is an area of intense study. Insights into kidney organogenesis have the potential to guide our understanding of the origin of congenital anomalies and enable the assembly of genetic diagnostic tools. A number of studies have delineated signalling nodes that regulate positional identities and cell fates of nephron progenitor and precursor cells, whereas cross-species comparisons have markedly enhanced our understanding of conserved and divergent features of mammalian kidney organogenesis. Greater insights into the complex cellular movements that occur as the proximal–distal axis is established have challenged our understanding of nephron patterning and provided important clues to the elaborate developmental context in which human kidney diseases can arise. Studies of kidney development in vivo have also facilitated efforts to recapitulate nephrogenesis in kidney organoids in vitro, by providing a detailed blueprint of signalling events, cell movements and patterning mechanisms that are required for the formation of correctly patterned nephrons and maturation of physiologically functional apparatus that are responsible for maintaining human health.