Chemistry and biology of orexin signaling.

Chemistry and biology of orexin signaling.
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DOI:
10.1039/c003468a
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发表时间:
2010-08
影响因子:
--
通讯作者:
Cai D
Cai D
中科院分区:
生物3区
文献类型:
--
作者:
Kodadek T;Cai D

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食欲素是一种神经激素,与其同源受体一起调节许多重要的生理过程,包括进食,睡眠,奖励寻求和能量稳态。食欲素受体最近成为重要的药物靶点。本文综述了近年来对食欲素信号转导机制的研究进展以及对食欲素信号转导机制的调控。
The orexins are neurohormones that, in concert with their cognate receptors, regulate a number of important physiological processes, including feeding, sleep, reward seeking and energy homeostasis. The orexin receptors have recently emerged as important drug targets. This review provides an overview of recent development in deciphering the biology of orexin signaling as well as efforts to manipulate orexin signaling pharmacologically.
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