Theory of mind and empathy in preclinical and clinical Huntington's disease
Theory of mind and empathy in preclinical and clinical Huntington's disease
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DOI：
10.1093/scan/nsv093
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Allain, Philippe
中科院分区：
文献类型：
--
作者：
Adjeroud, Najia;Besnard, Jeremy;Allain, Philippe
我们调查了亨廷顿病（HD）患者的认知和情感心理理论（ToM）和共情。同时还研究了心理理论绩效和执行技能之间的关系。16名临床前和23名临床HD患者以及39名健康受试者被分为2个对照组，给予法国改编的Yoni测试（Shamay-Tsoory，S.G.，Aharon-Peretz，J.（2007年）。认知和情感心理理论的分离性前额叶网络：一项损伤研究。Neuropsychologia，45（3），3054-67），它检查了一阶和二阶认知和情感心理理论处理在不同的条件下与物理控制条件。参与者还接受了移情问卷和认知测试，主要评估执行功能（抑制和心理灵活性）。临床HD患者在Yoni任务的一阶和二阶认知和情感ToM条件下比对照组犯了更多的错误，但没有表现出共情缺陷。然而，没有证据表明心理理论障碍与这些患者的认知缺陷有关。与对照组相比，临床前HD患者在ToM任务和同理心测量中未受损。我们的研究结果是一致的想法，受损的情感和认知心智化出现的临床表现的HD，但不一定是临床前阶段的一部分。此外，这些障碍似乎独立于执行功能障碍和同理心。
We investigated cognitive and affective Theory of Mind (ToM) and empathy in patients with premanifest and manifest Huntington's disease (HD). The relationship between ToM performance and executive skills was also examined. Sixteen preclinical and 23 clinical HD patients, and 39 healthy subjects divided into 2 control groups were given a French adaptation of the Yoni test (Shamay-Tsoory, S.G., Aharon-Peretz, J. (2007). Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia, 45(3), 3054-67) that examines first- and second-order cognitive and affective ToM processing in separate conditions with a physical control condition. Participants were also given questionnaires of empathy and cognitive tests which mainly assessed executive functions (inhibition and mental flexibility). Clinical HD patients made significantly more errors than their controls in the first- and second-order cognitive and affective ToM conditions of the Yoni task, but exhibited no empathy deficits. However, there was no evidence that ToM impairment was related to cognitive deficits in these patients. Preclinical HD patients were unimpaired in ToM tasks and empathy measures compared with their controls. Our results are consistent with the idea that impaired affective and cognitive mentalizing emerges with the clinical manifestation of HD, but is not necessarily part of the preclinical stage. Furthermore, these impairments appear independent of executive dysfunction and empathy.