Efficiency of maternal-fetal transfer of perfluoroalkyl and polyfluoroalkyl substances
Efficiency of maternal-fetal transfer of perfluoroalkyl and polyfluoroalkyl substances
复制标题
全氟烷基和多氟烷基物质母胎转移的效率
DOI：
10.1007/s11356-018-3686-3
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发表时间：
2019
影响因子：
5.8
通讯作者：
Tian Ying
中科院分区：
文献类型：
--
作者：
Wang Yiwen;Han Wenchao;Wang Caifeng;Zhou Yijun;Shi Rong;Bonefeld-Jorgensen Eva Cecilie;Yao Qian;Yuan Tao;Gao Yu;Zhang Jun;Tian Ying
全氟烷基和多氟烷基物质（PFAS）可以在怀孕期间从母亲转移到胎儿身上，并对胎儿发育产生不利影响。然而，PFASs母胎移植的有效性和影响因素尚不清楚。我们测量了369对母体和脐带血清中六种全氟烷基羧酸盐、三种全氟烷基磺酸盐和一种磺酰胺的水平，并在中国山东的一个前瞻性出生队列中通过官能团和碳链长度检查了PFAS的经胎盘转运效率（TTE）。在几乎所有样本中，在母体和脐带血清中都检测到所有10种PFAS。除全氟丁烷磺酸（PFBS）（r= 0.159）外，大多数PFAS的母体和脐带水平密切相关（相关系数[r]范围为0.485至0.908）。TTE受官能团和碳链长度的影响显著。与全氟烷基羧酸盐相比，全氟烷基磺酸盐的母体转移至胎儿的比率较低。碳链长度和TTE之间的U形关系，观察全氟烷基羧酸盐，而TTE和全氟烷基磺酸盐的碳链长度增加之间的单调下降趋势。PFAS可以很容易地通过胎盘。官能团和碳链长度是影响PFASs TTE的重要因素。
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) can be transferred from a mother to her fetus during pregnancy and adversely affect fetal development. However, the efficiency and influencing factors of PFASs maternal–fetal transfer remain unclear. We measured the levels of six perfluoroalkylcarboxylates, three perfluoroalkylsulfonates, and one sulfonamide in 369 pairs of maternal and umbilical cord serum and examined the transplacental transfer efficiency (TTE) of PFASs by the functional group and carbon chain length in a prospective birth cohort in Shandong, China. All ten PFASs were detected in both maternal and umbilical cord serum in nearly all samples. Maternal and cord levels were closely correlated (the correlation coefficient [r] ranging from 0.485 to 0.908) in most PFASs except perfluorobutane sulfonic acid (PFBS) (r= 0.159). TTE was significantly affected by the functional group and carbon chain length. Compared to perfluoroalkylcarboxylates, perfluoroalkylsulfonates had a lower ratio of maternal to fetal transfer. A U-shaped relationship between carbon chain length and TTE was observed for perfluoroalkylcarboxylates while a monotonic descending trend was identified between TTE and the increasing carbon chain length for perfluoroalkylsulfonates. PFASs can readily pass through the placenta. The functional group and carbon chain length are important determinants for the TTE of PFASs.