Indole diketopiperazine alkaloids from the deep-sea-derived fungus Aspergillus sp. FS445
Indole diketopiperazine alkaloids from the deep-sea-derived fungus Aspergillus sp. FS445
复制标题
来自深海真菌曲霉属的吲哚二酮哌嗪生物碱。
DOI：
10.1080/14786419.2021.1925271
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发表时间：
2021-05-03
影响因子：
2.2
通讯作者：
Zhang, Weimin
中科院分区：
文献类型：
--
作者：
Liu, Zhaoming;Chen, Yuchan;Zhang, Weimin
从深海真菌 Aspergillus sp. 中分离得到 12 种吲哚二酮哌嗪生物碱 (1-12)，其中包括 4 种新的阿司奇菌素 A-D (1、3、5 和 12)。 FS445。通过光谱分析阐明了它们的结构，并通过分析实验 ECD 数据以及量子化学计算确定了它们的绝对构型。化合物1、3和5代表通过酰亚胺键在11-NH处构建C-5单元的吲哚二酮哌嗪衍生物的第一个实例。对分离化合物的NO产生抑制活性进行了评估，化合物2-5、7和9表现出潜在的NO产生抑制活性，IC50值在20至90μM范围内。
Twelve indole diketopiperazine alkaloids (1-12) including four new ones aspechinulins A-D (1, 3, 5 and 12) were isolated from the deep-sea-derived fungus Aspergillus sp. FS445. Their structures were elucidated through spectroscopic analysis and the absolute configurations were determined by analyzing the experimental ECD data as well as the quantum chemical calculations. Compounds 1, 3 and 5 represented the first examples of indole diketopiperazine derivatives constructing a C-5 unit at 11-NH through an imide linkage. The NO production inhibitory activity of the isolated compounds was evaluated and compounds 2-5, 7 and 9 exhibited potential inhibitory activities against NO production with the IC50 values in the range of 20 similar to 90 mu M.