Coronary flow and coronary flow reserve measurements in humans with breath-held magnetic resonance phase contrast velocity mapping
Coronary flow and coronary flow reserve measurements in humans with breath-held magnetic resonance phase contrast velocity mapping
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DOI：
10.1002/mrm.1910370410
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发表时间：
1997-04-01
影响因子：
3.3
通讯作者：
Debatin, JF
中科院分区：
文献类型：
--
作者：
Davis, CP;Liu, PF;Debatin, JF
冠状动脉病变意义的客观证据可以通过缺血负荷试验获得。由于血流限制性狭窄已经经历了代偿性血管舒张以维持血流，因此对血管活性刺激的反应受到抑制。冠状动脉血流储备（CFR）反映了反应受限的程度，MRI技术可以准确、无创地测量冠状动脉的绝对容积流速，目的是评估无创测量冠状动脉容积流速的能力，并利用超快速、屏气分段k空间相位对比MR成像（PC-MRI）定量表征药物应激对冠状动脉血流的影响。10名健康志愿者使用超快速屏气PC-MRI进行检查。在静息状态和静脉注射潘生丁后，测量冠状动脉前降支（LAD）的冠状动脉容积流量。根据这些数据确定CFR。平均LAD容积流速从应用潘生丁前的38 +/- 11 ml/min增加到169 +/- 42 ml/min，平均CFR为5.0 +/- 2.6（中位数= 4.15）。本研究证明了屏气PC-MRI在心动周期内无创量化冠状动脉容积流速的可行性，可以量化药理学诱导的容积流速变化，从而量化CFR。
Objective evidence for coronary lesion significance can be obtained with ischemic stress testing, Since flow-limiting stenoses have already undergone compensatory vasodilatation to maintain flow, the response to vasoactive stimulation is dampened. The degree of response limitation is reflected by the coronary flow reserve (CFR), Absolute volume flow rates can be accurately and noninvasively measured with MRI techniques, The purpose was to assess the ability to measure coronary volume flow rate noninvasively, and characterize the effect of pharmacologic stress on coronary flow quantitatively by using ultrafast, breath-held segmented k-space phase-contrast-MR imaging (PC-MRI), Ten healthy volunteers were examined by using ultrafast breath-held PC-MRI. Coronary volume flow rates were measured in the anterior descending coronary artery (LAD) at rest and following intravenous administration of dipyridamole. CFR was determined based on these data. Mean LAD volume flow rates increased from 38 +/- 11 ml/min before application of dipyridamole to 169 +/- 42 ml/min, The mean CFR amounted to 5.0 +/- 2.6 (median = 4.15). This study demonstrates the feasibility of breath-held PC-MRI to noninvasively quantify coronary volume flow rates over the cardiac cycle, Pharmacologically induced changes in volume flow rate and thus CFR can be quantitated.