The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
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DOI：
10.1038/ni.1617
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发表时间：
2008-07-01
影响因子：
30.5
通讯作者：
Kile, Benjamin T.
中科院分区：
文献类型：
--
作者：
Loughran, Stephen J.;Kruse, Elizabeth A.;Kile, Benjamin T.
Ets相关基因（ERG）是一种重要的癌基因，编码Ets家族转录因子。涉及ERG的染色体重排见于急性髓细胞白血病、急性淋巴细胞白血病、尤文氏肉瘤和超过一半的前列腺癌;然而，Erg的正常生理功能尚不清楚。我们做了一个致敏的遗传筛选的小鼠造血干细胞功能的监管机构，并在这里报告Erg的种系突变。我们发现，Erg是确定的造血，成人造血干细胞功能和维持正常的外周血血小板数量所必需的。
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.