The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.
The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.
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氧化还原和硫醇状况对骨髓的影响：药理干预策略。
DOI：
10.1016/j.pharmthera.2010.09.008
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发表时间：
2011-02
影响因子：
13.5
通讯作者：
Tew, Kenneth D.
中科院分区：
文献类型：
--
作者：
Grek, Christina L.;Townsend, Danyelle M.;Tew, Kenneth D.
癌细胞氧化还原稳态的不平衡为抗癌药物的开发提供了新的机会。控制与氧化还原调节相关的严重剂量限制性毒性，包括骨髓抑制和免疫抑制，仍然是一个挑战。最近的证据表明氧化还原调节和巯基平衡在控制骨髓增殖、造血祖细胞动员和免疫应答的途径中起着关键作用。造血干细胞（HSC）的自我更新和分化依赖于细胞内活性氧（ROS）水平和生态位微环境。氧化还原状态和游离巯基：二硫键对的平衡在调节免疫应答和淋巴细胞活化、增殖和分化中是重要的。这一主题是本次审查的重点。氧化还原调节化疗药物作为骨髓增殖和免疫调节剂的潜力也包括在内。
Imbalances in cancer cell redox homeostasis provide a platform for new opportunities in the development of anticancer drugs. The control of severe dose-limiting toxicities associated with redox regulation, including myelosuppression and immunosuppression, remains a challenge. Recent evidence implicates a critical role for redox regulation and thiol balance in pathways that control myeloproliferation, hematopoietic progenitor cell mobilization, and immune response. Hematopoietic stem cell (HSC) self-renewal and differentiation is dependent upon levels of intracellular reactive oxygen species (ROS) and niche microenvironments. Redox status and the equilibrium of free thiol:disulfide couples is important in modulating immune response and lymphocyte activation, proliferation and differentiation. This subject matter is the focus of the present review. The potential of redox modulating chemotherapeutics as myeloproliferative and immunomodulatory agents is also covered.
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影响因子：
9.3
作者：
Dedieu S;Canron X;Rezvani HR;Bouchecareilh M;Mazurier F;Sinisi R;Zanda M;Moenner M;Bikfalvi A;North S
通讯作者：
North S
DOI：
10.1093/jnci/89.23.1789
发表时间：
1997-12-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Bailey, HH;Ripple, G;Wilding, G
通讯作者：
Wilding, G
影响因子：
5.4
作者：
Castellani, Patrizia;Angelini, Giovanna;Rubartelli, Anna
通讯作者：
Rubartelli, Anna
影响因子：
45.3
作者：
BAILEY, HH;MULCAHY, RT;SPRIGGS, DR
通讯作者：
SPRIGGS, DR
DOI：
10.1084/jem.189.11.1783
发表时间：
1999-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bertini R;Howard OM;Dong HF;Oppenheim JJ;Bizzarri C;Sergi R;Caselli G;Pagliei S;Romines B;Wilshire JA;Mengozzi M;Nakamura H;Yodoi J;Pekkari K;Gurunath R;Holmgren A;Herzenberg LA;Herzenberg LA;Ghezzi P
通讯作者：
Ghezzi P