Field comparison of immunodiagnostic and parasitological techniques for the detection of Schistosomiasis japonica in the People's Republic of China
Field comparison of immunodiagnostic and parasitological techniques for the detection of Schistosomiasis japonica in the People's Republic of China
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DOI：
10.4269/ajtmh.2007.76.1138
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Jiang, Qing-Wu
中科院分区：
文献类型：
--
作者：
Zhou, Yi-Biao;Yang, Mei-Xia;Jiang, Qing-Wu
采用Kato-Katz寄生虫学检查、间接血凝试验和酶联免疫吸附试验对中国疫区2个村的1,811人进行了血吸虫抗体检测。统计分析结果显示，间接血凝试验和粪便检查之间的卡帕指数在0.106~0.234之间，酶联免疫吸附试验和粪便检查之间的卡帕指数在0.037~0.134之间。IHA在A村和B村的敏感度分别为83.7%和92.3%，特异度为55.86/。A村和B村的敏感度分别为88.4%和96.2%，特异度分别为38.4%和38.4%。寻找一种能在中国地区现场应用的诊断试验是当务之急。
A total of 1,811 individuals from two villages located in the areas of China endemic for Schistosoma japonicum were analyzed by the Kato-Katz parasitologic examination, indirect hemagglutination assay (IHA), and enzyme-linked immunosorbent assay (ELISA). Statistical analysis of the results showed the kappa indices ranged from 0.106 to 0.234 between IHA and the stool examination and ranged from 0.037 to 0.134 between ELISA and the fecal examination. The sensitivity value of the IHA was 83.7% in Village A and 92.3% in Village B; the specificity value of the IHA was 55.86/. in Village A and 67.3% in Village B. The sensitivity value of the ELISA was 88.4% in Village A and 96.2% in Village B; the specificity value of the ELISA was 38.4% in both Village A and Village B. A search for a good diagnostic test that can be applied in field situations in China should be given high priority.