All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration.
All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration.
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DOI：
10.1186/s13619-020-00063-3
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发表时间：
2021-01-06
期刊：
影响因子：
--
通讯作者：
Peng J
中科院分区：
文献类型：
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作者：
Gao C;Peng J
肝脏是人体最大的内脏器官，是机体进行各种代谢活动和维持体内平衡的关键部位。肝脏疾病是对人类健康的巨大威胁。在部分肝切除术后，肝脏恢复其质量的能力已广泛应用于通过移除患者体内患病肝脏的受损部分或将健康肝脏的一部分移植到患者体内来治疗肝脏疾病。人们已经做出了巨大的努力来研究不同肝损伤模型中肝再生的生物学。关于肝再生过程中肝细胞的来源，令人信服的证据表明，不同的肝损伤模型动员不同亚型的肝细胞参与肝再生。在极端的肝细胞消融下，胆管上皮细胞可以经历去分化为肝祖细胞（LPC），然后LPC分化产生肝细胞。在这里，我们将重点总结在确定细胞类型有助于产生新的肝细胞在小鼠和斑马鱼肝再生过程中取得的进展。
Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partial hepatectomy has widely been applied in treating liver diseases either by removing the damaged part of a diseased liver in a patient or transplanting a part of healthy liver into a patient. Vast efforts have been made to study the biology of liver regeneration in different liver-damage models. Regarding the sources of hepatocytes during liver regeneration, convincing evidences have demonstrated that different liver-damage models mobilized different subtype hepatocytes in contributing to liver regeneration. Under extreme hepatocyte ablation, biliary epithelial cells can undergo dedifferentiation to liver progenitor cells (LPCs) and then LPCs differentiate to produce hepatocytes. Here we will focus on summarizing the progresses made in identifying cell types contributing to producing new hepatocytes during liver regeneration in mice and zebrafish.