The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
复制标题
DOI：
10.1016/j.cmet.2014.05.002
复制
发表时间：
2014-07-01
期刊：
影响因子：
29
通讯作者：
Murakami M
中科院分区：
文献类型：
--
作者：
Sato H;Taketomi Y;Ushida A;Isogai Y;Kojima T;Hirabayashi T;Miki Y;Yamamoto K;Nishito Y;Kobayashi T;Ikeda K;Taguchi R;Hara S;Ida S;Miyamoto Y;Watanabe M;Baba H;Miyata K;Oike Y;Gelb MH;Murakami M
代谢紊乱，包括肥胖和胰岛素抵抗，其基础是脂质代谢失调和低度炎症。通过微阵列搜索与肥胖相关的独特脂肪酶相关基因，我们发现肥胖小鼠的脂肪细胞中强烈诱导了两种分泌型磷脂酶A2s (sPLA2s)， PLA2G5和PLA2G2E。对Pla2g5−/−和Pla2g2e−/−小鼠的分析揭示了这些sPLA2s在饮食诱导的肥胖中独特的和以前未被认识到的作用。PLA2G5水解脂肪超载低密度脂蛋白中的磷脂酰胆碱，释放不饱和脂肪酸，阻止棕榈酸诱导的M1巨噬细胞极化。因此，PLA2G5使免疫平衡向M2状态倾斜，从而抵消脂肪组织炎症、胰岛素抵抗、高脂血症和肥胖。PLA2G2E改变少量脂蛋白磷脂、磷脂酰丝氨酸和磷脂酰乙醇胺，适度促进脂肪组织和肝脏的脂质积累。总的来说，“代谢sPLA2s”的鉴定将这个基因家族添加到作为代谢协调者的越来越多的脂溶酶列表中。
Metabolic disorders including obesity and insulin resistance have their basis in dysregulated lipid metabolism and low-grade inflammation. In a microarray search of unique lipase-related genes whose expressions are associated with obesity, we found that two secreted phospholipase A2s (sPLA2s), PLA2G5 and PLA2G2E, were robustly induced in adipocytes of obese mice. Analyses of Pla2g5−/− and Pla2g2e−/− mice revealed distinct and previously unrecognized roles of these sPLA2s in diet-induced obesity. PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization. As such, PLA2G5 tipped the immune balance toward an M2 state, thereby counteracting adipose tissue inflammation, insulin resistance, hyperlipidemia and obesiy. PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver. Collectively, the identification of “metabolic sPLA2s” adds this gene family to a growing list of lipolytic enzymes that act as metabolic coordinators.
登录
查看更多内容
淋巴组织磷脂酶A2组IID通过驱动抗炎脂质介质来解决接触性超敏反应。
DOI：
10.1084/jem.20121887
发表时间：
2013-06-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Miki Y;Yamamoto K;Taketomi Y;Sato H;Shimo K;Kobayashi T;Ishikawa Y;Ishii T;Nakanishi H;Ikeda K;Taguchi R;Kabashima K;Arita M;Arai H;Lambeau G;Bollinger JM;Hara S;Gelb MH;Murakami M
通讯作者：
Murakami M
影响因子：
20.1
作者：
Ahmed, W;Orasanu, G;Plutzky, J
通讯作者：
Plutzky, J
影响因子：
4.4
作者：
Balestrieri, Barbara;Maekawa, Akiko;Arm, Jonathan P.
通讯作者：
Arm, Jonathan P.
影响因子：
56.9
作者：
Haemmerle, G;Lass, A;Zechner, R
通讯作者：
Zechner, R
影响因子：
20.1
作者：
Miller AM;Asquith DL;Hueber AJ;Anderson LA;Holmes WM;McKenzie AN;Xu D;Sattar N;McInnes IB;Liew FY
通讯作者：
Liew FY