Predictive value of plasma B-type natriuretic peptide for ischemic stroke: A community-based longitudinal study
Predictive value of plasma B-type natriuretic peptide for ischemic stroke: A community-based longitudinal study
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DOI：
10.1016/j.atherosclerosis.2009.04.029
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发表时间：
2009-11-01
期刊：
影响因子：
5.3
通讯作者：
Okayama, Akira
中科院分区：
文献类型：
--
作者：
Takahashi, Tomohiro;Nakamura, Motoyuki;Okayama, Akira
目的：包括心房颤动在内的结构性心脏病是缺血性脑卒中的先兆。血浆B型利钠肽（BNP）已被报道在几种类型的结构性心脏病患者中升高。然而，血浆BNP对缺血性卒中的预测价值仍不清楚。我们研究了血浆BNP对社区居民adults.Methods中风未来发展的预测能力：这项以社区为基础的研究的受试者是从普通人群中招募的（n = 13，466）。在基线时测定血浆BNP水平和心血管危险因素。队列中缺血性卒中的发生率是从地区卒中登记数据中确定的。多因素考克斯回归分析进行分析血浆BNP水平和中风的风险之间的关系。结果：在平均随访期为2.8年，102名参与者（65名男性，37名女性）经历了首次缺血性中风。在男性中，校正经典心血管危险因素和房颤后，血浆BNP最高四分位数的缺血性卒中风险比（HR）显著升高（HR = 2.38; 95% CI = 1.07-5.29）。在女性中，血浆BNP水平与缺血性卒中风险之间的关系在校正有无房颤后具有边际意义（HR = 3.03，95%CI = 0.84-10.92，P = 0.09）。结论：血浆BNP水平升高可预测一般人群中男性缺血性卒中的风险。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Structural heart diseases including atrial fibrillation are precursors for ischemic stroke. Plasma B-type natriuretic peptide (BNP) has been reported to be increased in patients with several types of structural heart diseases. However, the predictive value of plasma BNP for ischemic stroke remains unknown. We have studied the predictive ability of plasma BNP for future development of stroke in community dwelling adults.Methods: Subjects of this community-based study were recruited from the general population (n = 13,466). Plasma BNP levels and cardiovascular risk factorswere determined at baseline. The incidence of ischemic stroke in the cohort was identified from regional stroke registry data. A multivariate Cox regression analysis was performed to analyze the relationship between plasma BNP levels and the risk of stroke.Results: During a mean follow-up period of 2.8 years, 102 participants (65 males, 37 females) experienced a first ischemic stroke. In men, after adjustment for classical cardiovascular risk factors and atrial fibrillation, the hazard ratio (HR) for ischemic stroke was significantly elevated in the highest plasma BNP quartile (HR = 2.38; 95% CI = 1.07-5.29). In women, the relationship between plasma BNP levels and risk of ischemic stroke was of marginal significance after adjusting for the presence or absence of atrial fibrillation (HR = 3.03; 95% CI = 0.84-10.92, P = 0.09).Conclusion: Elevated plasma BNP levels predict the risk of ischemic stroke within men from the general population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.