Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.
Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.
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流感A病毒NS1与宿主细胞蛋白之间相互作用的结构研究。
DOI：
10.3390/v15102063
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发表时间：
2023-10-07
期刊：
影响因子：
--
通讯作者：
Petit CM
中科院分区：
文献类型：
--
作者：
Blake ME;Kleinpeter AB;Jureka AS;Petit CM
甲型流感病毒对公共卫生构成持续威胁，每年都会引起流行病，并且该病毒成为下一次大流行的威胁始终存在。由于抗药性的增加，我们以前使用的几种抗病毒药物已经失效。对不易受突变影响的新抗病毒药物存在强烈需求。实现这一目标的一个策略是基于结构的药物开发。通过了解蛋白质结构的微小细节，我们可以开发针对最保守、最关键区域的抗病毒药物，以获得最大的长期成功机会。一个有希望的IAV靶标是毒力蛋白非结构蛋白1（NS 1）。NS 1通过与许多宿主蛋白质的相互作用而增强致病性，并且许多由此产生的复合物已被证明对毒力至关重要。在这篇综述中，我们涵盖了NS 1-宿主蛋白复合物的结构特点，迄今为止。通过将这些结构集中在一个地方，我们的目标是突出这一领域的药物发现的力量，沿着仍然有待填补的空白。
The Influenza A virus is a continuous threat to public health that causes yearly epidemics with the ever-present threat of the virus becoming the next pandemic. Due to increasing levels of resistance, several of our previously used antivirals have been rendered useless. There is a strong need for new antivirals that are less likely to be susceptible to mutations. One strategy to achieve this goal is structure-based drug development. By understanding the minute details of protein structure, we can develop antivirals that target the most conserved, crucial regions to yield the highest chances of long-lasting success. One promising IAV target is the virulence protein non-structural protein 1 (NS1). NS1 contributes to pathogenicity through interactions with numerous host proteins, and many of the resulting complexes have been shown to be crucial for virulence. In this review, we cover the NS1-host protein complexes that have been structurally characterized to date. By bringing these structures together in one place, we aim to highlight the strength of this field for drug discovery along with the gaps that remain to be filled.
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