Glomerular microfibrils in renal disease: a comparative electron microscopic study.
Glomerular microfibrils in renal disease: a comparative electron microscopic study.
复制标题
肾脏疾病中的肾小球微纤维：比较电子显微镜研究。
作者：
H. Hsu;J. Churg
微原纤维是结缔组织的常见成分，在肾小球中很少被描述。从结构上看，微原纤维是平均直径为 12 nm、透明核心和深色外围的纤维管。高分辨率电子显微镜，包括对肾活检组织进行的立体显微镜，证明在几种肾小球疾病中毛细血管壁内皮下和系膜中存在微原纤维。这些疾病的特点是内层内板增宽或内皮与基底膜分离，其中包括移植肾小球病、局灶节段性肾小球硬化（包括与马凡综合征相关的病例）、先兆子痫毒血症以及较少见的溶血尿毒症综合征和恶性高血压。微原纤维的数量通常与内皮下增宽的程度相关。
Microfibrils are a common component of connective tissue that have been described only rarely in the renal glomerulus. Structurally, microfibrils are fibrotubules with an average diameter of 12 nm, a lucid core, and a dark periphery. High resolution electron microscopy, including stereo microscopy performed on renal biopsy tissues, demonstrated the presence of microfibrils under the endothelium of the capillary walls and in the mesangium in several glomerular diseases. These diseases were characterized by widening of lamina rara interna or separation of the endothelium from the basement membrane, among them transplant glomerulopathy, focal segmental glomerulosclerosis (including a case associated with Marfan syndrome), preeclamptic toxemia, and less frequently hemolytic-uremic syndrome and malignant hypertension. The number of microfibrils generally correlated with the degree of subendothelial widening.