Changes in visual acuity and intra-ocular pressure following bleb-related infection: the Japan Glaucoma Society Survey of Bleb-related Infection Report 2
Changes in visual acuity and intra-ocular pressure following bleb-related infection: the Japan Glaucoma Society Survey of Bleb-related Infection Report 2
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滤泡相关感染后视力和眼压的变化：日本青光眼协会滤泡相关感染调查报告2
DOI：
10.1111/aos.12079
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发表时间：
2013
影响因子：
3.4
通讯作者：
Mori K; Japan Glaucoma Society Survey of Bleb-related Infection
中科院分区：
文献类型：
--
作者：
Yamamoto T;Kuwayama Y;Nomura E;Tanihara H;Mori K; Japan Glaucoma Society Survey of Bleb-related Infection
目的：确定发生滤泡相关感染 12 个月后视力和眼压 (IOP) 的变化。方法：作为日本青光眼协会滤泡相关感染调查的一部分，分析了从 146 名滤泡相关感染患者的 146 只眼睛获得的数据。通过多元逻辑回归分析来确定与视力不良预后、眼压升高以及 III 期相关的因素。结果：I、II、IIIa 和 IIIb 期感染在感染后 12 个月时 logMAR 平均分别增加 0.140、0.440、1.099 和 1.122。 logMAR 在 IIIb 期感染后 6 个月和 12 个月时显着较差（分别为 p = 0.002 和 p = 0.003；Wilcoxon 符号秩检验）以及 IIIa 期感染后 6 个月（p = 0.036）。 IIIa 期和 IIIb 期感染后 IOP 均显着升高（对于 IIIa 期，分别在 6 个月和 12 个月时，p = 0.028 和 p = 0.008；对于 IIIb 期，p = 0.002 和 p = 0.005）。多重逻辑回归分析显示，III 期和培养阳性是视力不良结果的显着危险因素（优势比：9.26 和 6.29），III 期是 IOP 增加的预后因素（优势比：8.33）。假性晶状体或无晶状体与 III 期和 IIIb 期感染显着相关（比值比：2.85 和 6.30）。结论：III 期滤泡相关感染在发育后 12 个月内导致显着的视力丧失和 IOP 升高。因此，应采取预防措施，特别是在人工晶状体或无晶状体的情况下。
Purpose:To identify changes in visual acuity and intra‐ocular pressure (IOP) 12 months after the development of bleb‐related infection.Methods:Data obtained from 146 eyes of 146 patients with bleb‐related infection were analyzed as a part of the Japan Glaucoma Society Survey of Bleb‐related Infection. Multiple logistic regression analysis was conducted to identify factors associated with poor prognosis in visual acuity and increased IOP and for being stage III.Results:The logMAR increased by a mean of 0.140, 0.440, 1.099 and 1.122 at 12 months postinfection for stage I, II, IIIa and IIIb infections, respectively. The logMAR was significantly worse at 6 and 12 months postinfection in stage IIIb (p = 0.002 and p = 0.003, respectively; Wilcoxon signed‐rank test) and at 6 months postinfection in stage IIIa (p = 0.036). The IOP was significantly elevated following infection in both stage IIIa and stage IIIb (p = 0.028 and p = 0.008 at 6 and 12 months, respectively, for stage IIIa; p = 0.002 and p = 0.005 for stage IIIb). The multiple logistic regression analysis revealed that being stage III and positive culture were significant risk factors for poor outcome for visual acuity (Odds ratio: 9.26 and 6.29, respectively) and that being stage III was a prognostic factor for increased IOP (Odds ratio: 8.33). Pseudophakia or aphakia was significantly associated with stage III and stage IIIb infections (Odds ratio: 2.85 and 6.30).Conclusions:Stage III bleb‐related infection causes significant visual loss and IOP elevation within 12 months after development. Therefore, preventative measures should be taken, especially in cases that are pseudophakic or aphakic.