Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes.

Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes.
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只见树木，不见森林：肾脏癌基因组与治疗结果的关系。

DOI：
10.1158/1078-0432.ccr-14-0056
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发表时间：
2014
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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通讯作者：
Rathmell,WKimryn
Rathmell,WKimryn
中科院分区：
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文献类型：
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作者：
Chism,DavidD;Rathmell,WKimryn

文献摘要

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肾细胞癌是一种异质性疾病，组织调查提供了可能预测治疗反应的线索。对5个异常值的肿瘤基因组分析表明，tsc1和mtor基因发生了改变，并揭示了肿瘤的保守进化。临床癌症研究；20 (7);1721 - 3。AACR©2014。
Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of theTSC1andmTORgenes and reveals insights into the conserved evolution of tumors.Clin Cancer Res; 20(7); 1721–3. ©2014 AACR.