Effects of larvicidal and larval nutritional stresses on Anopheles gambiae development, survival and competence for Plasmodium falciparum.
Effects of larvicidal and larval nutritional stresses on Anopheles gambiae development, survival and competence for Plasmodium falciparum.
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DOI：
10.1186/s13071-016-1514-5
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发表时间：
2016-04-23
影响因子：
3.2
通讯作者：
Dabiré KR
中科院分区：
文献类型：
--
作者：
Vantaux A;Ouattarra I;Lefèvre T;Dabiré KR
许多研究表明，幼虫发育的环境可以影响成虫的特征，从而导致病原体的传播。我们研究了两种环境压力（杀幼虫和营养压力）如何相互作用影响冈比亚按蚊（以前称为冈比亚按蚊）。gambiae S分子形式）生活史性状及其对恶性疟原虫的田间分离株的易感性。幼虫饲养在存在或不存在亚致死浓度的杀幼虫剂和高和低的食物方案。对恶性疟原虫的发育时间、个体大小、成虫存活率和能力进行了评估。低摄食量下个体发育时间长，发育成功率低，个体个体较小，但杀幼虫剂暴露对这些性状无显著影响。然而，杀幼虫剂暴露影响个体大小与营养压力的相互作用。雌虫存活率受配子体血症、寄生虫暴露和幼虫饮食之间的相互作用以及配子体血症、寄生虫暴露和杀幼虫应激之间的相互作用以及配子体血症、杀幼虫暴露和幼虫饮食之间的相互作用的影响。在感染后7天解剖的951只雌性动物中，559只（58.78%）携带寄生虫。寄生虫的流行率显着影响的杀幼虫压力和幼虫的饮食之间的相互作用。事实上，低食物方案下的女性比高食物方案下的女性有更高的患病率，这种差异在杀幼虫压力下更大。这两种应力不影响寄生虫强度。我们发现幼虫营养和杀幼虫压力以复杂的方式影响蚊子生活史特征，这可能会极大地影响恶性疟原虫的传播。进一步的研究结合使用杀幼虫剂的实地试验和蚊子实验性感染，将更准确地了解这种病媒控制工具对疟疾传播的影响。本文的在线版本（doi：10.1186/s13071-016-1514-5）包含补充材料，可供授权用户使用。
Many studies have shown that the environment in which larvae develop can influence adult characteristics with consequences for the transmission of pathogens. We investigated how two environmental stresses (larviciding and nutritional stress) interact to affect Anopheles gambiae (previously An. gambiae S molecular form) life history traits and its susceptibility for field isolates of its natural malaria agent Plasmodium falciparum. Larvae were reared in the presence or not of a sub-lethal concentration of larvicide and under a high and low food regimen. Development time, individual size, adult survival and competence for P. falciparum were assessed. Individuals under low food regimen took more time to develop, had a lower development success and were smaller while there was no main effect of larvicide exposure on these traits. However, larvicide exposure impacted individual size in interaction with nutritional stress. Female survival was affected by the interaction between gametocytemia, parasite exposure and larval diet, as well as the interaction between gametocytemia, parasite exposure and larvicidal stress, and the interaction between gametocytemia, larvicidal exposure and larval diet. Among the 951 females dissected 7 days post-infection, 559 (58.78 %) harboured parasites. Parasite prevalence was significantly affected by the interaction between larvicidal stress and larval diet. Indeed, females under low food regimen had a higher prevalence than females under high food regimen and this difference was greater under larvicidal stress. The two stresses did not impact parasite intensity. We found that larval nutritional and larvicidal stresses affect mosquito life history traits in complex ways, which could greatly affect P. falciparum transmission. Further studies combining field-based trials on larvicide use and mosquito experimental infections would give a more accurate understanding of the effects of this vector control tool on malaria transmission. The online version of this article (doi:10.1186/s13071-016-1514-5) contains supplementary material, which is available to authorized users.