The role of the mannose-binding lectin in innate immunity
The role of the mannose-binding lectin in innate immunity
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DOI：
10.1086/431987
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发表时间：
2005-11-15
影响因子：
11.8
通讯作者：
Ezekowitz, RAB
中科院分区：
文献类型：
--
作者：
Takahashi, K;Ezekowitz, RAB
包括甘露糖结合凝集素（MBL）在内的先天免疫系统可识别多种感染因子的多种分子模式，并能够将其与自身区分开来。MBL是一种肝源性血清蛋白，分泌到血清中，在诱导抗原特异性免疫之前激活免疫应答。在人群中的间接证据表明，低血清MBL水平易感染。为了分析MBL在体内的作用，我们创建了MBL-裸小鼠，并在各种条件下用感染攻击这些小鼠。我们的研究结果表明，MBL起着重要的作用，作为一个第一线主机防御某些传染性病原体。此外，MBL可能是炎症的关键调节因子，超出了感染中的预期作用。
The innate immune system, which includes mannose-binding lectin (MBL), recognizes a broad range of molecular patterns on a broad range of infectious agents and is able to distinguish them from self. MBL is a liver-derived serum protein and is secreted into the serum, where it can activate an immune response before the induction of antigen-specific immunity. Circumstantial evidence in human populations suggests that low serum levels of MBL predispose to infection. To analyze the role of MBL in vivo, we created MBL-null mice and challenged these mice with infection under various conditions. Our results suggest that MBL plays an important role as a first-line host defense against certain infectious agents. In addition, it is likely that MBL is a key regulator of inflammation beyond expected roles in the infection.