Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]raclopride
Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]raclopride
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DOI：
10.1016/j.biopsych.2005.05.003
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发表时间：
2005-12-01
影响因子：
10.6
通讯作者：
Kaye, WH
中科院分区：
文献类型：
--
作者：
Frank, GK;Bailer, UF;Kaye, WH
背景：多项证据支持多巴胺 (DA) 功能紊乱可能导致神经性厌食症 (AN) 患者体重、进食、运动活动和奖赏的改变。方法：为了评估可能与性状相关的紊乱，但避免营养不良的混杂影响，将 10 名从 AN 中康复的女性 (REC AN) 与 12 名健康对照女性 (CW) 进行了比较。使用[C-11]雷氯必利的正电子发射断层扫描来评估DA D2/D3受体结合。结果：从 AN 中恢复的女性在前腹侧纹状体中的 [C-11]雷氯必利结合潜力显着高于 CW。对于 REC AN，[C-11]雷氯必利结合电位与背侧尾状核和背壳核的伤害避免呈正相关。结论：这些数据支持以下可能性：突触内 DA 浓度降低或 D2/D3 受体密度或亲和力增加与 AN 相关，并且可能有助于 AN 中发现的特征性伤害避免或体力活动增加。最有趣的是，患有 AN 的个体可能存在与 DA 相关的奖励机制紊乱，从而导致进食行为的享乐性改变以及禁欲、快感缺乏的气质。
Backgound: Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN).Methods: To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women who were recovered from AN (REC AN) were compared with 12 healthy control women (CW). Positron emission tomography with [C-11]raclopride was used to assess DA D2/D3 receptor binding. Results: The women who were recovered from AN had significantly higher [C-11]raclopride binding potential in the antero-ventral striatum than CW. For REC AN, [C-11]raclopride binding potential was positively related to harm avoidance in the dorsal caudate and dorsal putamen.Conclusions: These data lend support for the possibility that decreased intrasynaptic DA concentration or increased D2/D3 receptor density or affinity is associated with AN and mighty contribute to the characteristic harm avoidance or increased physical activity found in AN. Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behaviour and theirascetic, anhedonic temperament.