Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma:: Promoter hypermethylation with clinical correlation in 100 cases
Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma:: Promoter hypermethylation with clinical correlation in 100 cases
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DOI：
10.1158/1055-9965.epi-082-3
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发表时间：
2004-01-01
影响因子：
3.8
通讯作者：
Fan, CY
中科院分区：
文献类型：
--
作者：
Ai, LB;Quynh, NV;Fan, CY
共济失调-毛细血管扩张突变（ATM）基因产物是一种充分表征的肿瘤抑制因子，在维持基因组稳定性中起关键作用。我们最近已经证明ATM启动子是培养的肿瘤细胞中表观遗传沉默的靶点。在此，我们发现ATM启动子的异常甲基化发生在头颈部鳞状细胞癌的显著百分比（25%）。ATM启动子甲基化的存在与早期诊断年龄和总生存率降低有统计学意义的相关性，特别是在早期肿瘤中。这些发现表明，ATM启动子高甲基化发生在头颈部鳞状细胞癌，这一特点是一个潜在的有用的预后标志物在这种肿瘤类型。
The Ataxia-telangiectasia-mutated (ATM) gene product is a well-characterized tumor suppressor that plays a key role in maintenance of genomic stability. We have recently documented that the ATM promoter is a target for epigenetic silencing in cultured tumor cells. Here we show that aberrant methylation of the ATM promoter occurs in a significant percentage (25%) of head and neck squamous cell carcinomas. The presence or methylated ATM promoter shows a statistically significant correlation with an earlier age of initial diagnosis and decreased overall survival, particularly in early-stage tumors. These findings indicate that ATM promoter hypermethylation occurs in head and neck squamous cell carcinoma, and this feature is a potentially useful prognostic marker in this tumor type.