Environmental manganese exposure and associations with memory, executive functions, and hyperactivity in Brazilian children
Environmental manganese exposure and associations with memory, executive functions, and hyperactivity in Brazilian children
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DOI：
10.1016/j.neuro.2018.02.002
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发表时间：
2018-12-01
期刊：
影响因子：
3.4
通讯作者：
Abreu, Neander
中科院分区：
文献类型：
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作者：
de Carvalho, Chrissie Ferreira;Oulhote, Youssef;Abreu, Neander
锰是一种必需元素，然而，高水平的锰与儿童较低的神经心理表现和行为问题有关。我们调查了7至12岁长期接触空气中锰的儿童发锰浓度与神经心理和行为表现之间的关系。神经心理学测试包括：言语记忆、抑制控制、认知灵活性、言语流畅性和运动功能。采用Conners简明教师评定量表对学生的多动行为进行评定。对儿童头发中的锰(MNH)浓度和接触某锰铁合金厂空气中的锰进行了分析，并与测试分数进行了相关性分析。调整了潜在混杂因素的多变量线性模型显示，MNH水平的升高与言语记忆成绩的下降有关，通过干扰后的自由回忆(Beta=-1.8；95%CI：-3.4，-0.2)和延迟效应(Beta=-2.0；95%CI：-3.7，-0.2)来衡量，后者表示随着时间的推移信息的丢失。此外，我们还在测量言语记忆的三个分测验中发现了性别效应修正的模式：干扰后自由回忆分数、干扰效应和延迟效应(均为P<；0.10)。总体而言，这些结果表明，长期接触空气中的锰可能与言语记忆和多动行为的表现较差有关。(C)2018爱思唯尔B.V.保留所有权利。
Manganese (Mn) is an essential element, however high levels of Mn have been associated with lower neuropsychological performance and behavioral problems in children. We investigated the associations between hair Mn concentrations and neuropsychological and behavioral performances among children with long-term exposure to airborne Mn aged between 7 and 12 years. Neuropsychological performance included tests of: verbal memory, inhibitory control, cognitive flexibility, verbal fluency, and motor function. We used the Conners Abbreviated Rating Scale for teachers to assess students' behaviors of hyperactivity. Hair manganese (MnH) concentrations in children and exposure to airborne manganese from a ferro-manganese alloy plant were analyzed and correlated with tests scores. Multivariable linear models adjusting for potential confounders showed that elevated levels of MnH were associated with lower performance in verbal memory, as measured by the free recall after interference (beta = - 1.8; 95% CI: - 3.4, - 0.2), which indicates susceptibility to interference, and Delayed Effect (beta = -2.0; 95% CI: -3.7, -0.2), representing a loss of information over time. Additionally, we found patterns of effect modification by sex in three subtests measuring verbal memory: the free recall after interference score, Interference Effect, and Delayed Effect (all at p < 0.10). Overall, the results suggest that long-term airborne Mn exposure may be associated with lower performance in verbal memory, and hyperactivity behaviors. (C) 2018 Elsevier B.V. All rights reserved.