Aromatase, breast cancer and obesity: a complex interaction.
Aromatase, breast cancer and obesity: a complex interaction.
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DOI：
10.1016/j.tem.2011.10.003
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发表时间：
2012-02
影响因子：
10.9
通讯作者：
Zhao, Hong
中科院分区：
文献类型：
--
作者：
Bulun, Serdar E.;Chen, Dong;Moy, Irene;Brooks, David C.;Zhao, Hong
肥胖与乳腺中芳香化酶的异常高表达、局部雌激素产生增加以及乳腺增生和癌症的易感性有关。绝经后妇女肥胖增加可能触发诱导芳香化酶表达的信号通路。在乳腺脂肪成纤维细胞中，增加的TNF产生可能诱导远端芳香化酶启动子，而增加的局部PGE2产生可能诱导近端启动子区域。本文综述了乳腺脂肪组织芳香化酶基因表达的调控机制，以及乳腺癌上皮细胞与周围脂肪成纤维细胞间的旁分泌相互作用。这些信号通路的系统表征将有助于鉴定潜在的药物靶点，以选择性地减少芳香酶表达和过量的雌激素产生，具有治疗益处。
Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer. Increased adiposity in postmenopausal women may trigger signaling pathways that induce aromatase expression. In breast adipose fibroblasts, increased TNF production may induce the distal aromatase promoter, whereas increased local PGE2 production may induce the proximal promoter region. We review here the mechanisms that control aromatase gene expression in breast adipose tissue, and the paracrine interactions between malignant breast epithelial cells and the surrounding adipose fibroblasts. Systematic characterization of these signaling pathways will facilitate the identification of potential drug targets to selectively reduce aromatase expression and excessive estrogen production, with therapeutic benefit.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
2.7
作者：
Chand, Ashwini L.;Herridge, Kerrie A.;Clyne, Colin D.
通讯作者：
Clyne, Colin D.
影响因子：
--
作者：
Chen, Dong;Reierstad, Scott;Bulun, Serdar E.
通讯作者：
Bulun, Serdar E.
影响因子：
5.8
作者：
Agarwal, VR;Bulun, SE;Simpson, ER
通讯作者：
Simpson, ER
DOI：
10.1016/s0960-0760(00)00036-4
发表时间：
2000-04-01
影响因子：
4.1
作者：
Geisler, J;Berntsen, H;Lonning, PE
通讯作者：
Lonning, PE