CEREBRAL BLOOD-VOLUME MAPS OF GLIOMAS - COMPARISON WITH TUMOR GRADE AND HISTOLOGIC-FINDINGS
CEREBRAL BLOOD-VOLUME MAPS OF GLIOMAS - COMPARISON WITH TUMOR GRADE AND HISTOLOGIC-FINDINGS
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DOI：
10.1148/radiology.191.1.8134596
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发表时间：
1994-04-01
期刊：
影响因子：
19.7
通讯作者：
ROSEN, BR
中科院分区：
文献类型：
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作者：
ARONEN, HJ;GAZIT, IE;ROSEN, BR
目得：为了评估磁共振（MR）脑血容量（CBV）地图在胶质瘤评估中的实用性，材料和方法：19例经组织学证实的胶质瘤患者的CBV地图是从静脉注射钆基造影剂后用回波平面自旋回波成像获得的动态MR图像集计算的。高分级组（n = 13）的最大CBV范围为0.82 - 5.40，低分级组（n = 6）的最大CBV范围为1.01 - 1.21。差异有统计学意义。最大CBV与有丝分裂活动和血管，但不与细胞增殖，内皮细胞增殖，坏死，或cellularity.CONCLUSION：MR CBV地图提供了诊断信息，无法与传统的MR成像在6例，并提供了一个功能参数，用于评估胶质瘤级别和区域的焦点活动。
PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas.MATERIALS AND METHODS: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material.RESULTS: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity.CONCLUSION: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.