A population dynamics model of cell-cell adhesion incorporating population pressure and density saturation
A population dynamics model of cell-cell adhesion incorporating population pressure and density saturation
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DOI：
10.1016/j.jtbi.2019.04.023
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发表时间：
2019-08-07
影响因子：
2
通讯作者：
Trush, Olena
中科院分区：
文献类型：
--
作者：
Carrillo, Jose A.;Murakawa, Hideki;Trush, Olena
我们讨论了几个连续的细胞粘附模型的基础上的微观假设。我们提出了一个改进这些模型，导致尖锐的前线和不同的细胞类型群体之间的混合入侵前线。该模型是基于本地化的排斥和非本地的吸引力，由于在微观水平上的粘附力的基本原则。新模型能够定性和定量地捕获Katsunuma等人的实验。（2016）。我们还回顾了这些模型在发育生物学组织生长其他领域的应用。最后，我们探讨了由于细胞-细胞排斥所产生的定性行为。(C)2019爱思唯尔有限公司版权所有。
We discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type populations. The model is based on basic principles of localized repulsion and nonlocal attraction due to adhesion forces at the microscopic level. The new model is able to capture both qualitatively and quantitatively experiments by Katsunuma et al. (2016). We also review some of the applications of these models in other areas of tissue growth in developmental biology. We finally explore the resulting qualitative behavior due to cell-cell repulsion. (C) 2019 Elsevier Ltd. All rights reserved.