Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour
Specific contributions of the basal forebrain corticopetal cholinergic system to electroencephalographic activity and sleep/waking behaviour
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DOI：
10.1046/j.1460-9568.2002.02310.x
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发表时间：
2002-12-01
影响因子：
3.4
通讯作者：
Sarter, M
中科院分区：
文献类型：
--
作者：
Berntson, GG;Shafi, R;Sarter, M
本研究检查了基础前脑皮质胆碱能投射在大鼠跨睡眠/唤醒状态的皮质脑电图活性调节中的作用。该投影的选择性病变是由免疫毒素192 IgG-撒泊蛋白的局部核内注射引起的。病变释放了隔septo-Hampocampal胆碱能系统，以及肩部核中的p75受体非胆碱能神经元。相对于假性对照动物，具有基础前脑胆碱能神经元病变的大鼠表现出高频脑电图活性的显着降低，其特征是伽马脑电图降低。病变并没有显着改变睡眠状态和醒来状态的总体比例，因为行为定义，但是在包括REM样期间在内的所有阶段，高频脑电图活动的衰减都是显而易见的。结果与以下观点一致：基底前脑皮质胆碱能系统对皮质地幔具有一般的活化作用。尽管该系统对于睡眠/唤醒阶段转换可能不是必不可少的，但它确实会影响与这些阶段相关的皮质状态。
The present study examined the role of the basal forebrain corticopetal cholinergic projection in the regulation of cortical electroencephalographic activity across sleep/wake states in rats. Selective lesions of this projection were effected by local intraparenchymal infusions of the immunotoxin 192 IgG-saporin. Lesions spared the septo-hippocampal cholinergic system, as well as p75-receptor-bearing noncholinergic neurons in the suprachiasmatic nucleus. Relative to sham-lesioned control animals, rats with lesions of basal forebrain cholinergic neurons displayed a significant reduction in high frequency EEG activity, characterized especially by a reduction in gamma EEG power. Lesions did not significantly alter the overall proportion of sleeping and waking states as defined behaviourally, but the attenuation of high frequency EEG activity was apparent across all stages, including REM-like periods. Results are consistent with the view that the basal forebrain corticopetal cholinergic system exerts a general activational effect on the cortical mantle. Although this system may not be essential for sleep/wake stage-switching, it does impact on the cortical states associated with those stages.