Galectins. Structure and function of a large family of animal lectins.
Galectins. Structure and function of a large family of animal lectins.
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发表时间：
1994-08
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通讯作者：
S. Barondes;D. Cooper;M. Gitt;H. Leffler
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作者：
S. Barondes;D. Cooper;M. Gitt;H. Leffler
凝集素是一种结合特定碳水化合物结构的蛋白质，因此可以识别动物组织中大量表达的特定糖缀合物。大多数动物凝集素可分为四个不同的家族(1):c型凝集素（包括选择性凝集素）；p型凝集素;pentraxins;和凝集素(2)，以前称为s型或S-Lac凝集素(1)。这篇简短综述的目的是提供一个框架，以整合对聚集素的多样性、结构和功能的快速增长的知识。虽然这里的重点是哺乳动物的凝集素，但对其他物种的凝集素的研究也取得了重要进展，包括线虫(3)和海绵(4)。
Lectins are proteins that bind to specific carbohydrate structures and can thus recognize particular glycoconjugates among the vast array expressed in animal'tissues. Most animal lectins can be clas- sified into four distinct families (1): C-type lectins (including the selectins); P-type lectins; pentraxins; and galectins (2), formerly known as S-type or S-Lac lectins (1). The purpose of this short review is to provide a framework for integrating the rapid increase in knowledge of the diversity, structure, and function of the galectins. While the emphasis here is on mammalian galectins, impor- tant advances are also being made in studies of galectins in other species, including nematode (3) and sponge (4).