Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls.
Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls.
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DOI：
10.1016/j.xfre.2020.05.006
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Blesson CS
中科院分区：
文献类型：
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作者：
Chappell NR;Barsky M;Shah J;Peavey M;Yang L;Sangi-Haghpeykar H;Gibbons W;Blesson CS
目的：探讨多囊卵巢综合征(PCOS)患者与对照组相比胚胎形态动力学是否发生改变。回顾性队列分析。在三级医院环境下的单一学术生育诊所。年龄和体重指数匹配的接受体外受精的患者，根据鹿特丹标准诊断为多囊卵巢综合征。对伴有高雄激素血症的多囊卵巢综合征患者进行亚分析。对64例多囊卵巢综合征患者的990枚胚胎进行鉴定，并与对照组的628枚胚胎进行比较。没有。胚泡发育的时间到了。多囊卵巢综合征患者的胚胎在t7、t8和t9有较快的生长速度；所有其他形态运动点相似。多囊卵巢综合征患者也获得了更多的卵母细胞。两组受精率和囊胚率无明显差异。多囊卵巢综合征患者的流产率较高(38.1%比18.8%)。高雄激素性PCOS患者在T5、T6、T7、T8、T9和桑拿期的生长速度较快。患有多囊卵巢综合征的妇女的胚胎生长速度更快，直到9细胞期，而患有高雄激素的多囊卵巢综合征妇女的胚胎生长更快，直到桑拿期。多囊卵巢综合征患者的流产率也较高。在PCOS患者中，早期胚胎发育的改变与生育力和产科结局的改变是一致的，可能是由于卵巢卵泡中的高雄激素微环境所致。
To investigate if patients with polycystic ovary syndrome (PCOS) have altered embryo morphokinetics when compared with controls. Retrospective cohort analysis. Single academic fertility clinic in a tertiary hospital setting. Age- and body mass index–matched patients who underwent in vitro fertilization diagnosed with PCOS using the Rotterdam criteria. A subanalysis was performed on patients with PCOS with hyperandrogenemia. Sixty-four patients with PCOS were identified with 990 embryos that were matched with 64 control patients with 628 embryos. None. Time to blastulation. Embryos from women with PCOS displayed faster growth rate at t7, t8, and t9; all other morphokinetic points were similar. Patients with PCOS also had a higher number of oocytes retrieved. No differences were seen in the fertilization rate or blastulation rate. Patients with PCOS had a higher miscarriage rate (38.1% in PCOS vs. 18.8% in controls). Patients with hyperandrogenic PCOS showed a faster growth rate at t5, t6, t7, t8, t9, and morula. Embryos from women with PCOS grew faster until 9-cell stage and women with hyperandrogenic PCOS until morula. Patients with PCOS also showed a higher miscarriage rate. The alterations in early embryo development are consistent with altered fertility and obstetric outcomes in the population with PCOS and may be due to the hyperandrogenic microenvironment in the ovarian follicle.