Internal Calvarial Bone Distraction in Rabbits with Delayed‐Onset Coronal Suture Synostosis
Internal Calvarial Bone Distraction in Rabbits with Delayed‐Onset Coronal Suture Synostosis
复制标题
迟发性冠状缝骨融合兔的颅内骨牵引
DOI：
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发表时间：
1998
影响因子：
3.6
通讯作者：
M. Siegel
中科院分区：
文献类型：
--
作者：
W. Losken;M. Mooney;J. Zoldos;A. Tschakaloff;A. Burrows;T. Smith;G. Cooper;R. Kapucu;M. Siegel
&NA;最近的研究已经确定了一个亚群的颅缝早闭个体谁表现出进行性或迟发性骨缝早闭和轻度颅面生长异常。这些人可能是非摘除，牵引成骨治疗的良好候选人。本研究旨在通过在家族性迟发性颅缝早闭症兔模型中使用颅骨内牵引来验证这一假设。数据收集自159只家兔：71只正常对照组，72只延迟发作冠状缝骨性结合，8只延迟发作冠状缝骨性结合和冠状缝切除术，8只延迟发作冠状缝骨性结合和牵张。在10日龄时，所有家兔的额鼻缝、冠状缝和前矢状缝两侧均放置汞合金标记。在25日龄时，通过5 mm宽缝合切除术或牵张成骨术完成矫正。一个内部牵引装置固定在额骨和顶骨上，并以平均0.10 mm/天的速度间歇性激活，持续42天（共4.11 mm）。在10、25、42和84日龄时拍摄系列X线照片。结果显示，与其他三组（0.07 mm/天）相比，迟发型骨性结合家兔的冠状缝生长率（0.04 mm/天）显著降低（p < 0.01）。缝线切除术的家兔和牵张术的家兔表现出相似的冠状缝反应。然而，从42至84天的年龄，与其他三组相比，牵引兔显示在穹窿缝的增长减少和颅穹窿宽度，颅穹窿形状和颅底成角的异常增长模式。结果表明，尽管采用间歇性牵张成骨术治疗迟发性骨性结合的家兔保持了正常的冠状缝生长速率，但未获得正常的成人颅面结构。这种异常生长可能是牵张过程中相邻缝线的生长矢量和压缩力改变的结果。这些结果表明，不进行皮质切除的牵张成骨可能是进行性、迟发性骨性连接患者的一种治疗选择，但应研究和开发产生低水平、持续牵张力的内部器械。（Plast。重建102：1109，1998）。
&NA; Recent studies have identified a subpopulation of craniosynostotic individuals who exhibit progressive or delayed‐onset synostosis and mild craniofacial growth abnormalities. These individuals may be good candidates for nonextirpation, distraction osteogenesis therapy. The present study was designed to test this hypothesis by using internal calvarial bone distraction in a rabbit model with familial delayed‐onset craniosynostosis. Data were collected from 159 rabbits: 71 normal controls, 72 with delayed‐onset coronal suture synostosis, 8 with delayed‐onset coronal suture synostosis and coronal suturectomy, and 8 with delayed‐onset coronal suture synostosis and distraction. At 10 days of age, all rabbits had amalgam markers placed on both sides of the frontonasal, coronal, and anterior lambdoidal sutures. At 25 days of age, correction was accomplished through either a 5‐mm‐wide suturectomy or distraction osteogenesis. An internal distraction appliance was fixed to the frontal and parietal bones and percutaneously and intermittently activated at an average of 0.10 mm/day for 42 days (4.11 mm total). Serial radiographs were taken at 10, 25, 42, and 84 days of age. Results revealed that rabbits with delayed‐onset synostosis had significantly (p < 0.01) reduced coronal suture growth rates (0.04 mm/day) compared with the other three groups (0.07 mm/day). Rabbits with suturectomy and rabbits with distraction showed similar coronal suture responses. However, from 42 to 84 days of age, rabbits with distraction showed reduced growth at the vault sutures and abnormal growth patterns in cranial vault width, cranial vault shape, and cranial base angulation compared with the other three groups. Results demonstrated that, although the normal coronal suture growth rate was maintained in rabbits with delayed‐onset synostosis using intermittent distraction osteogenesis, normal adult craniofacial structure was not achieved. Such anomalous growth was probably a result of altered growth vectors and compressive forces at adjacent sutures during distraction. These findings suggest that distraction osteogenesis without corticotomy may be a treatment alternative in individuals with progressive, delayed‐onset synostosis, but that internal appliances that generate low‐level, continuous distractive forces should be investigated and developed. (Plast. Reconstr. Surg. 102: 1109, 1998.)
DOI：
10.1597/1545-1569_1995_032_0235_gotcvi_2.3.co_2
发表时间：
1995
期刊：
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
影响因子：
--
作者：
Burrows,AM;Mooney,MP;Smith,TD;Losken,HW;Siegel,MI
通讯作者：
Siegel,MI
先天性冠状缝连接兔的出生后颅底变化。
DOI：
--
发表时间：
1996
期刊：
Journal of craniofacial genetics and developmental biology.
影响因子：
--
作者：
Smith,TD;Mooney,MP;Burrows,AM;Losken,HW;Siegel,MI
通讯作者：
Siegel,MI