Efficacy of stratum corneum lipid supplementation on human skin
Efficacy of stratum corneum lipid supplementation on human skin
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DOI：
10.1034/j.1600-0536.2002.470303.x
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发表时间：
2002-09-01
影响因子：
5.5
通讯作者：
Parra, J
中科院分区：
文献类型：
--
作者：
Coderch, L;De Pera, M;Parra, J
最近的研究表明，在老龄化人口或皮肤干燥的人中补充角质层的细胞间脂肪可以刺激皮肤的功能。这项工作支持了两种不同的角质层脂质混合物(合成角质层脂混合物，SSCL和内毛脂肪提取物，IWL)作为脂质体在两个不同年龄组的健康皮肤上的增强能力。评估了健康皮肤对洗涤剂所致皮炎的保护作用。在体内长期研究中，通过皮肤失水率和电容来评估这些制剂的效果。只有当所应用的制剂被构建为脂质体时，才能获得保水能力的增加。对于老化的皮肤来说，这一点更加明显。随后的SLS暴露反映了对健康皮肤的保护，使其免受洗涤剂引起的皮炎的影响。含有天然神经酰胺混合物的IWL比配方中只有一种神经酰胺的SSCL获得了略好的结果。所有这些结果都支持皮肤脂肪补充剂的有益效果，因为它们在成分和配方结构上都与角质层中的脂肪相似。
Recent studies suggest that supplementing intercellular lipids of the stratum corneum in ageing populations or in people with dry skin can stimulate the functioning of the skin. This work lends support to the reinforcement capacity of two different stratum corneum lipid mixtures (synthetic stratum corneum lipid mixtures, SSCL, and internal wool lipid extracts, IWL) formulated as liposomes on healthy skin of two differently aged groups of individuals. Protection of healthy skin against detergent-induced dermatitis was evaluated. Transepidermal water loss and capacitance were used to evaluate the effect of these formulations in in vivo long-term studies. Increase in water-holding capacity is obtained only when the formulations applied are structured as liposomes. This is slightly more pronounced for aged skin. Subsequent SLS exposure reflected the protection of healthy human skin against detergent-induced dermatitis. Slightly better results were obtained with IWL containing a mixture of natural ceramides than with SSCL with only one ceramide present in the formulation. All these results support the beneficial effects of skin lipid supplementation given their resemblance to the lipids in the stratum corneum both in composition and in the structuring of the formulation.