Silicate-apatite composite layers on external fixation rods and in vitro evaluation using fibroblast and osteoblast.
Silicate-apatite composite layers on external fixation rods and in vitro evaluation using fibroblast and osteoblast.
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DOI：
10.1002/jbm.a.32436
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
Xiupeng Wang;A. Ito;Y. Sogo;Xia Li;A. Oyane
中科院分区：
文献类型：
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作者：
Xiupeng Wang;A. Ito;Y. Sogo;Xia Li;A. Oyane
用含Na(2)SiO(3)的过饱和磷酸钙溶液在商用阳极氧化钛棒上形成硅酸盐-磷灰石层。随着过饱和磷酸钙溶液中Na(2)SiO(3)浓度的增加，钛棒上的硅析出量从0增加到0.07+/-0.02微克/厘米(2)，而钙和磷的析出量分别从11.6+/-1.6和5.7+/-2.0微克/厘米(2)下降到2.6+/-0.5和3.0+/-1.0微克/厘米(2)。硅酸盐-磷灰石复合层在体外具有促进成纤维细胞增殖和成骨细胞增殖分化的作用，有望作为外固定针的涂层，降低体内针道感染率。
A silicate-apatite layer was formed on commercially available anodically oxidized titanium rods using Na(2)SiO(3)-containing supersaturated calcium phosphate solutions. With the increase in the concentration of Na(2)SiO(3) in the supersaturated calcium phosphate solutions, the amounts of silicon that precipitated on the titanium rods increased from 0 to 0.07 +/- 0.02 microg/cm(2); meanwhile, the amounts of calcium and phosphorus that precipitated on the titanium rods decreased from 11.6 +/- 1.6 and 5.7 +/- 2.0 microg/cm(2) to 2.6 +/- 0.5 and 3.0 +/- 1.0 microg/cm(2), respectively. The present silicate-apatite composite layers, which demonstrated increased fibroblastic proliferation and osteoblastic proliferation and differentiation in vitro, are promising as coating layers on external fixation pins for decreasing the pin tract infection rate in vivo.