Ras Oncogene and Inflammation: Partners in Crime
Ras Oncogene and Inflammation: Partners in Crime
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DOI：
10.4161/cc.4.6.1714
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发表时间：
2005-04
期刊：
影响因子：
4.3
通讯作者：
Anke Sparmann;D. Bar-Sagi
中科院分区：
文献类型：
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作者：
Anke Sparmann;D. Bar-Sagi
众所周知，RAS癌基因通过刺激肿瘤细胞的生长、存活和运动来促进肿瘤转化。然而，目前的研究表明，RAS在恶性转化中的作用超出了这些细胞固有的影响，包括建立一个促肿瘤的宿主环境。我们最近证明，RAS诱导的趋化因子白介素8(CXCL-8/IL-8)的分泌引起局部炎症反应，这对新生血管和肿瘤的持续生长至关重要。我们的数据确定了RAS癌基因促进肿瘤-宿主相互作用的新机制，这是癌症进展所必需的，并表明CXCL-8可以作为体内RAS活性的替代标记物。
It is well established that Ras oncogenes facilitate neoplastic conversion by stimulating tumor cell growth, survival and motility. However, current studies have indicated that the role of Ras in malignant transformation extends beyond these cell-intrinsic effects to include the establishment of a pro-tumorigenic host environment. We have recently demonstrated that Ras-induced secretion of the chemokine Interleukin-8 (CXCL-8/IL-8) elicits a local inflammatory reaction that is critical for neo-vascularization and sustained tumor growth. Our data identify a novel mechanism by which the Ras oncogene promotes tumor-host interactions that are essential for cancer progression, and suggest that CXCL-8 could serve as a surrogate marker for in-vivo Ras activity.