Different MOG35-55 concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-β in mice CNS despite unchanged clinical course
Different MOG35-55 concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-β in mice CNS despite unchanged clinical course
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DOI：
10.1016/j.cellimm.2014.12.009
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发表时间：
2015-02-01
影响因子：
4.3
通讯作者：
Ferreira, Ana Paula
中科院分区：
文献类型：
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作者：
Dias, Alyria Teixeira;Ribeiro De Castro, Sandra Bertelli;Ferreira, Ana Paula
多发性硬化症（MS）表现出不同的临床过程。实验性自身免疫性脑脊髓炎（EAE）是一种研究多发性硬化的模型，可以通过不同的方案诱导，表现出不同的细胞因子和抗体产生。这种异质性所涉及的因素尚不清楚。MUG浓度在慢性EAE模型中触发调节反应的相关性不精确。本研究的目的是研究100或300 μ g MOG（35-55）是否可以诱导不同的EAE谱。MUG浓度的改变能够改变趋化因子、细胞因子、细胞百分比、炎性浸润和调节反应的发展的模式。然而，这些变化无法改变反应的强度，这解释了两种浓度下疾病的慢性进展。本研究中提出的结果有助于理解触发EAE的复杂机制，并为各种形式的MS的发病机制提供见解。All rights reserved.
Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. The factors involved in this heterogeneity remain unclear. The relevance of MUG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. The aim of this study was investigate if 100 or 300 mu g of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MUG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. The results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS. (C) 2015 Elsevier Inc. All rights reserved.