Quantitative 2D and 3D Phase Contrast MRI: Optimized Analysis of Blood Flow and Vessel Wall Parameters
Quantitative 2D and 3D Phase Contrast MRI: Optimized Analysis of Blood Flow and Vessel Wall Parameters
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DOI：
10.1002/mrm.21778
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Stalder, A. F.;Russe, M. F.;Markl, M.
由于有限的时空分辨率和信噪比（SNR），CINE相位对比（PC）-MRI数据的量化是一项具有挑战性的任务。在这项工作中提出的方法结合了B样条插值和绿色定理，以提供优化的量化血流和血管壁参数。B样条模型提供了测量的三个方向的血液速度到血管轮廓上的最佳导数，如矢量壁剪切应力（WSS）计算所需。在一项19名志愿者参与的研究中，使用高时空分辨率平面二维（2D）CINE-PC（类似于1.4 x 1.4 mm（2）/24.4 ms）和低分辨率3D-CINE-PC（类似于2.8 x 1.6 x 3 MM 3/48.6 ms）以及三维速度编码，对沿着整个胸主动脉分布的8个平面进行了评价。合成数据，误差传播，个体间，模态间，观察者间的变异性被用来评估该方法的可靠性和重现性。虽然MR测量噪声的影响很小，但PC-MRI的有限分辨率导致系统性WSS低估。体内数据表明，2D-和3D-CINE-PC以及观察者之间的流量和WSS非常一致，并证实了该方法的可靠性。沿着主动脉的WSS分析显示存在占10- 20%的周向WSS分量。动脉粥样硬化患者的初步结果表明，该方法有可能用于了解心血管疾病的形成和进展。Magn Reson Med 60：1218-1231，2008。(C)2008威利利斯公司
Quantification of CINE phase contrast (PC)-MRI data is a challenging task because of the limited spatiotemporal resolution and signal-to-noise ratio (SNR). The method presented in this work combines B-spline interpolation and Green's theorem to provide optimized quantification of blood flow and vessel wall parameters. The B-spline model provided optimal derivatives of the measured three-directional blood velocities onto the vessel contour, as required for vectorial wall shear stress (WSS) computation. Eight planes distributed along the entire thoracic aorta were evaluated in a 19-volunteer study using both high-spatiotemporal-resolution planar two-dimensional (2D)CINE-PC (similar to 1.4 x 1.4 mm(2)/24.4 ms) and lower-resolution 3D-CINE-PC (similar to 2.8 x 1.6 x 3 MM3/48.6 ms) with three-directional velocity encoding. Synthetic data, error propagation, and inter-individual, intermodality, and interobserver variability were used to evaluate the reliability and reproducibility of the method. While the impact of MR measurement noise was only minor, the limited resolution of PC-MRI introduced systematic WSS underestimations. In vivo data demonstrated close agreement for flow and WSS between 2D- and 3D-CINE-PC as well as observers, and confirmed the reliability of the method. WSS analysis along the aorta revealed the presence of a circumferential WSS component accounting for 10-20%. Initial results in a patient with atherosclerosis suggest the potential of the method for understanding the formation and progression of cardiovascular diseases. Magn Reson Med 60:1218-1231, 2008. (C) 2008 Wiley-Liss, Inc.