Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia
Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia
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DOI：
10.1212/01.wnl.0000156945.39471.2c
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发表时间：
2005-04-12
期刊：
影响因子：
9.9
通讯作者：
Mantegazza, R
中科院分区：
文献类型：
--
作者：
Antozzi, C;Frassoni, C;Mantegazza, R
通过免疫沉淀和大鼠脑免疫标记，胸腺瘤相关神经性肌强直和电压门控钾通道（Kv1.2和Kv1.6）抗体的患者成功地用免疫吸附和环磷酰胺治疗。奇怪的是，谷氨酸脱羧酶抗体，在发病时没有，后来出现。僵硬的人综合征是不存在的，但快速眨眼反射恢复表明增强脑干兴奋性。胸腺瘤相关性神经性肌强直产生的抗体范围更丰富，抗体出现的时间更复杂，比以前怀疑的。
A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected.