Hypocalcaemia, alcohol drinking and viroimmune responses in ART recipients.
Hypocalcaemia, alcohol drinking and viroimmune responses in ART recipients.
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ART 接受者的低钙血症、饮酒和病毒免疫反应。
DOI：
10.1016/j.alcohol.2012.07.004
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Malow,Robert
中科院分区：
文献类型：
--
作者：
Míguez,MaríaJosé;Burbano-Levy,Ximena;Carmona,Talita;Quiros,Clery;Thompson,Michelle;Lewis,JohnE;Asthana,Desharatan;Rodríguez,Allan;Valiathan,Ranjini;Malow,Robert
与艾滋病毒和抗逆转录病毒治疗相关的代谢紊乱非常普遍。不幸的是，研究主要集中在心脏代谢问题，忽视了其他重要领域。事实上，尽管免疫-钙-骨骼界面与艾滋病毒感染者（PLWH）具有潜在相关性，但其研究尚未充分。采用病例对照方法，招募了 200 名接受医疗护理的感染者，并通过分析基线数据，根据危险酒精摄入量与非危险酒精摄入量（HAU 与非 HAU）和钙 (Ca) 水平进行分层。该群体被选为代表相对“纯粹”的 HAU，使用最少的药物且没有精神病诊断。有了这些狭窄的参数，我们发现证据表明，与非 HAU 相比，HAU 显着增加 TNF-α 水平（2.8 ± 0.6 与 1.9 ± 0.3 pg/ml，p = 0.05）并降低血钙水平（9 ± 0.6 与 9.4 ± 0.5，p = 0.03）。我们的分析还表明，TNF-α 水平升高表明慢性炎症与低钙血症相关（hypoCa <8.6）。尽管hypoCa的患病率有限，但这些发现具有临床意义，因为hypoCA PLWH表现出CD4（253±224 vs. 417.7±281，p=0.02）、B细胞（147±58 vs. 248±151，p=0.03）和NK细胞（146.8±90 vs.与钙正常的患者相比，CD8 水平升高（902.5 ± 438 vs. 699 ± 510，p = 0.09），为 229 ± 148，p = 0.008。此外，钙对病毒载量的影响也很明显，hypoCA 表现出最高的载量（140,187 ± 111 vs. 35,622 ± 7770 HIV 拷贝，p = 0.01）。多变量分析证实了hypoCa在预测病毒免疫参数中的重要性。本文提供了第一个证据，证明hypoCa 解释了HAART 接受者中病毒免疫指标的一些变化，并表明hypoCa 可能介导了酒精的有害作用。
Metabolic perturbations associated with HIV and antiretroviral therapies are widespread. Unfortunately, research has predominantly focused in cardiometabolic problems, neglecting other important areas. In fact, the immune-calcium–skeletal interface has been understudied despite its potential relevance in people living with HIV (PLWH). Using a case-control methodology, 200 PLWH receiving medical care were enrolled and stratified according to hazardous vs. non-hazardous alcohol intake (HAU vs. non-HAU) and calcium (Ca) levels by analyzing baseline data. The group was chosen to represent relatively "pure" HAU with minimal drug use and no psychiatric diagnoses. With these narrow parameters in place, we found evidence that HAU significantly increases TNF-α levels compared to Non-HAU (2.8 ± 0.6 vs. 1.9 ± 0.3 pg/ml, p = 0.05) and decreases blood Ca levels (9 ± 0.6 vs. 9.4 ± 0.5, p = 0.03). Our analyses also suggest that chronic inflammation, as indicated by increased TNF-α levels, is associated with hypocalcemia (hypoCa <8.6). Despite the limited prevalence of hypoCa, these findings are clinically significant given that hypoCA PLWH exhibited decreased CD4 (253 ± 224 vs. 417.7 ± 281, p = 0.02), B cells (147 ± 58 vs. 248 ± 151, p = 0.03) and NK cells (146.8 ± 90 vs. 229 ± 148, p = 0.008) and elevated CD8 (902.5 ± 438 vs. 699 ± 510, p = 0.09) compared to those with normal calcium. Furthermore, calcium effects on viral load were also evident with hypoCA exhibiting the highest loads (140,187 ± 111 vs. 35,622 ± 7770 HIV copies, p = 0.01). Multivariate analyses confirmed the significance of hypoCa in predicting viroimmune parameters. This paper provides the first evidence that hypoCa accounts for some of the variation in viroimmune measures in HAART recipients and suggests that hypoCa may be mediating alcohol's deleterious effects.
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DOI：
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DOI：
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发表时间：
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期刊：
Alcoholism, clinical and experimental research.
影响因子：
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