THE ROLE OF SERINE HYDROXYMETHYLTRANSFERASE IN CELL-PROLIFERATION - DNA-SYNTHESIS FROM SERINE FOLLOWING MITOGENIC STIMULATION OF LYMPHOCYTES
THE ROLE OF SERINE HYDROXYMETHYLTRANSFERASE IN CELL-PROLIFERATION - DNA-SYNTHESIS FROM SERINE FOLLOWING MITOGENIC STIMULATION OF LYMPHOCYTES
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DOI：
10.1007/bf01117006
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发表时间：
1981-01-01
影响因子：
4
通讯作者：
SNELL, K
中科院分区：
文献类型：
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作者：
EICHLER, HG;HUBBARD, R;SNELL, K
放射性从[3- 14 C]丝氨酸掺入核酸的时间过程与植物血凝素（PHA）刺激人外周血淋巴细胞促有丝分裂后的DNA合成平行。与未受刺激的对照细胞相比，经PHA刺激的淋巴细胞中的丝氨酸羟甲基转移酶活性升高约4倍。显然，淋巴细胞与其他增殖细胞系统一样，可以重新合成Ser，用于促有丝分裂刺激后核苷酸生物合成途径。
The time-course of incorporation of radioactivity from [3-14C]serine into nucleic acids parallels DNA synthesis following mitogenic stimulation of human peripheral blood lymphocytes by phytohemagglutinin (PHA). The activity of serine hydroxymethyltransferase was elevated about 4-fold in PHA-stimulated lymphocytes compared to that in unstimulated control cells. Apparently lymphocytes, in common with other proliferating cell systems, may synthesize Ser de novo for utilization in pathways of nuceotide biosynthesis following mitogenic stimulation.