Antitumor abscopal effects in mice induced by normal tissue irradiation using pulsed streamer discharge plasma
Antitumor abscopal effects in mice induced by normal tissue irradiation using pulsed streamer discharge plasma
复制标题
脉冲流光放电等离子体照射正常组织对小鼠的抗肿瘤远隔作用
DOI：
10.1088/1361-6463/ac4c23
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ono Ryo
中科院分区：
文献类型：
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作者：
Jinno Reima;Komuro Atsushi;Yanai Hideyuki;Ono Ryo
在放疗和等离子体治疗中偶尔观察到抗肿瘤的远位效应。它是一种由肿瘤辐射诱导的远程抗肿瘤效应，可延迟其他远程非辐射肿瘤的生长。在这项研究中，证明了正常组织（非肿瘤）的等离子体照射也会导致远位效应。当脉冲流光放电照射到没有肿瘤存在的小鼠的左侧时，小鼠结肠直肠癌CT 26肿瘤在其右侧肢体的生长被延迟。这种远位效应对于等离子体照射前具有小肿瘤的小鼠是显著的，而对于等离子体照射前具有大肿瘤的小鼠是不显著的。将正常组织照射诱导的远位效应与直接肿瘤照射诱导的抗肿瘤效应进行比较。与我们的预期相反，在本实验条件下，正常组织照射延迟肿瘤生长的效果与直接肿瘤照射相同或更大。
An antitumor abscopal effect is occasionally observed in radiotherapy and plasma treatment. It is a remote antitumor effect induced by tumor irradiation that delays the growth of other distant, nonirradiated tumors. In this study, it was demonstrated that the plasma irradiation of normal tissues (not tumors) also leads to an abscopal effect. When a pulsed streamer discharge was irradiated to the left flanks of mice where no tumor existed, the growth of murine colorectal carcinoma CT26 tumors in their right limbs was delayed. This abscopal effect was significant for mice with small tumors before plasma irradiation, whereas it was not significant for those with large tumors before plasma irradiation. The abscopal effect induced by normal tissue irradiation was compared to the antitumor effect induced by direct tumor irradiation. Contrary to our expectation, normal tissue irradiation delayed the tumor growth equally or more than the direct tumor irradiation under the present experimental conditions.