Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.
Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.
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DOI：
10.2174/1566524015666150303002556
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发表时间：
2015-01
影响因子：
2.5
通讯作者：
Hiroki Shiwaku;H. Okazawa
中科院分区：
文献类型：
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作者：
Hiroki Shiwaku;H. Okazawa
DNA损伤修复受损是某些类型的神经退行性疾病、智能障碍和精神疾病的常见病理内表型。功能失调的DNA修复和DNA损伤，包括DNA双链断裂，与转录功能障碍和异常DNA甲基化有关。神经干细胞DNA修复受损会导致小头畸形或小脑性共济失调。此外，成熟神经元中的DNA修复缺陷和DNA损伤会导致进行性认知障碍，这可能是阿尔茨海默病、亨廷顿病和其他聚谷氨酰胺疾病的共同特征。精神分裂症患者GABA能神经元DNA氧化损伤和DNA修复基因表达改变。这些发现表明，DNA修复受损是神经系统疾病常见的病理内表型，DNA损伤可能导致不同的疾病症状，取决于时间和受影响的细胞类型。
Impaired DNA damage repair is a common pathological endophenotype of some types of neurodegenerative diseases, intellectual disabilities, and psychiatric diseases. Dysfunctional DNA repair and DNA damage, including DNA double-stranded breaks, are linked to transcriptional dysfunction and abnormal DNA methylation. Impaired DNA repair in neural stem cells leads to microcephaly or cerebellar ataxia. Furthermore, DNA repair defects and DNA damage in mature neurons lead to progressive cognitive impairment, which might be a common feature of Alzheimer's disease, Huntington's disease, and other polyglutamine diseases. Oxidative DNA damage and altered DNA repair gene expression are observed in GABAergic neurons in schizophrenia. These findings indicate that impaired DNA repair is a common pathological endophenotype of neurological diseases, and that DNA damage might lead to diverse disease symptoms dependent on timing and the affected cell type.