Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression
Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression
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DOI：
10.1016/j.bbrc.2009.06.073
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发表时间：
2009-09-11
影响因子：
3.1
通讯作者：
Sasaguri, Shiro
中科院分区：
文献类型：
--
作者：
Radhakrishnan, Geethalakshmi;Yamamoto, Morio;Sasaguri, Shiro
海水中的溶解有机物(DOM)可以定义为通过亚微米孔径过滤器的有机物的一部分。在这项研究中，我们研究了来自太平洋石油的海水中的DOM(Feel)对血小板聚集和动脉粥样硬化进展的影响。DSW通过一系列过滤器，然后通过十八烷基氯8过滤器：乙醇中的残留物质被命名为C18可提取DOM(C18-DOM)。我们的研究表明，C18-DOM处理显著抑制了血小板聚集、P-选择素表达和COX-1活性。C18-DOM可增加血管内皮细胞中抗动脉粥样硬化分子--血红素加氧酶-1的表达，提示C18-DOM具有阿司匹林样活性。此外，我们的体内研究表明，C18-DOM喂养显着减缓了动脉粥样硬化的进展。我们的研究证明了海洋DOM的一种新的生物学效应，这具有几个重要的意义，包括一种可能的治疗动脉粥样硬化的策略。(C)2009年，爱思唯尔公司出版。
Dissolved organic matter (DOM) in seawater can be defined as the fraction of organic matter that passes through a filter Of Sub micron pore size. In this study, we have examined the effect of DOM of (feel) seawater (DSW) from Pacific Ocean oil platelet aggregation and atherosclerosis progression. DSW was passed through a series of filters and then through an Octadecyl Cl 8 filter: the retained substance In ethanol was designated as C18 extractable DOM (C18-DOM). Our studies showed that C18-DOM treatment inhibited platelet aggregation, P-selectin expression and activity of COX-1 significantly. C18-DOM increased the expression of anti-atherogenic molecule namely heme oxygenase-1 in endothelial cells and all these data showed that C18-DOM is exhibiting aspirin-like effects. Moreover our in vivo studies showed that C18-DOM feeding slowed remarkably the progression of atherosclerosis. Our study demonstrated a novel biological effect of oceanic DOM, which has several important implications, including a possible therapeutic strategy for atherosclerosis. (C) 2009 Published by Elsevier Inc.