Somatic mutations
Somatic mutations
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作者：
F. Cramer
THE attractions of acetylcholinemediated neurotransmission as a model system for probing the molecular aspects of neurobiology are many. Not only is acetylcholine the least'putative'of neurotransmit 暗 ers but there already exists a wealth of information on its release from nerve terminals, its po! rtsynaptic receptors and its inactivation by acetylcholinesterase. In considerable part this is due to the electric organ of fishes such as Torpedo spp, which po. c; sess an exceedingly rich cholinergic innervation. Without Torpedo, EMBO would surely not have had the nerve to invent the quasi-discipline of Molecular Neurobiology*.Ultrastructural studies of the postsynaptic membranes of the electric organ of Torpedo have already revealed structures that can be tentatively identified as the acetylcholine receptors in situ. These consist of intramembranous particles on the cytoplasmic face of freeze-fractured membranes and a lattice-like structure on the surface of excitable microsacs derived from the organ. J. Heuser and S.