Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China
Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China
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DOI：
10.1007/s13277-010-0079-8
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Jiang, Wen-qi
中科院分区：
文献类型：
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作者：
Qiu, Miao-zhen;Xu, Rui-hua;Jiang, Wen-qi
尽管恶性肿瘤与血液学异常相关，但一些临床研究无法检测到这种关系。本研究的目的是检测常见实体瘤患者治疗前血液学异常的患病率，并确定这种情况是否可用于预后评估。我们确定了2000年1月至2009年8月中山大学肿瘤防治中心确诊为实体瘤（乳腺癌、肝细胞癌、鼻咽癌、食管癌、胃癌、宫颈癌、子宫内膜癌、肾细胞癌和非小细胞肺癌）的所有患者。对所有受试者的白色血细胞、血小板和血红蛋白浓度水平进行了研究。我们确定了3，180例实体瘤患者和285例良性疾病患者进行最终分析。实体瘤患者中白细胞增多、贫血和血小板增多的百分比分别为4.0%至25.6%、3.3%至29.2%和2.1%至9.7%。多因素考克斯分析显示贫血是乳腺癌（P = 0.006）、肝细胞癌（P = 0.002）、鼻咽癌（P = 0.008）和食管癌（P = 0.001）患者的独立预后因素。白细胞增多是宫颈癌患者的独立预后因素（P = 0.007）。中国实体瘤患者血液学异常的发生率相对低于西方国家。治疗前贫血或白细胞增多可作为预测某些实体瘤患者结局的有用标志物。
Despite the fact that malignancies are associated with hematological abnormalities, some clinical studies have been unable to detect such a relation. The aim of our study was to detect the prevalence of pretreatment hematologic abnormalities in patients with common solid tumors and to determine if such a profile could be used for prognostic evaluations. We identified all patients in Cancer Center of Sun Yat-sen University who were diagnosed as solid tumors (breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma, esophageal carcinoma, gastric cancer, cervical carcinoma, endometrial cancer, renal cell carcinoma, and non-small cell lung cancer) between January 2000 and August 2009. All subjects were investigated regarding levels of white blood cells, platelets, and hemoglobin concentration. We identified 3,180 patients with solid tumors and 285 patients with benign diseases for the final analysis. The percentages of leukocytosis, anemia, and thrombocytosis in patients with solid tumors ranged from 4.0% to 25.6%, 3.3% to 29.2%, and 2.1% to 9.7%, respectively. The multivariate Cox analysis revealed that anemia was an independent prognostic factor in patients with breast cancer (P = 0.006), hepatocellular carcinoma (P = 0.002), nasopharyngeal carcinoma (P = 0.008), and esophageal carcinoma (P = 0.001). Leukocytosis was an independent prognostic factor in patients with cervical cancer (P = 0.007). The incidence of hematological abnormalities in Chinese patients with solid tumors was relatively lower than that of the counterparts in the Western countries. A pretreatment anemia or leukocytosis can serve as a useful marker to predict outcome of patients in some of the solid tumors.