Methamphetamine induces chronic corticostriatal depression: too much of a bad thing.
Methamphetamine induces chronic corticostriatal depression: too much of a bad thing.
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甲基苯丙胺会诱发慢性皮质纹状体抑郁：太多是一件坏事。
DOI：
10.1016/j.neuron.2008.03.014
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发表时间：
2008
期刊：
影响因子：
16.2
通讯作者：
Carelli,ReginaM
中科院分区：
文献类型：
--
作者：
Day,JeremyJ;Carelli,ReginaM
药物成瘾的主要理论认为，重复的药物暴露会在大脑奖励过程中产生长期的稳态失调，而这种失调会通过药物再给药而正常化。在这一期的《神经元》杂志中，Bamford和他的同事描述了一种新的神经生物学底物，可能有助于这种效应。
Leading theories of drug addiction propose that repeated drug exposure produces a long-lasting homeostatic dysregulation in brain reward processing that is normalized by drug readministration. In this issue ofNeuron, Bamford and colleagues describe a novel neurobiological substrate that may contribute to this effect.